Gene interactions and pathways from curated databases and text-mining

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APP — NEUROD4

Text-mined interactions from Literome

Trudeau et al., Environ Health Perspect 2002 (Alzheimer Disease) : APLP-2 and the amyloid precursor protein (APP) regulate neuronal differentiation and are also implicated in the genesis of Alzheimer disease in humans
Adlerz et al., Brain Res Mol Brain Res 2003 (Neuroblastoma) : We observed that retinoic acid ( RA ) -induced neuronal differentiation of human SH-SY5Y cells resulted in increased expression of APP , APLP1 and APLP2
Marutle et al., Proc Natl Acad Sci U S A 2007 (Alzheimer Disease) : Thus, successful neuroplacement therapy for AD may require regulating APP expression to favorable levels to enhance neuronal differentiation of HNSCs. Phenserine, a recently developed cholinesterase inhibitor ( ChEI ), has been reported to reduce APP levels in vitro and in vivo
Moya et al., Dev Biol 1994 : In vitro studies have suggested that APP can participate in cellular adhesion and may thus contribute to neuronal differentiation in cultured cells