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IL8 — STAT3

Text-mined interactions from Literome

O'Brien et al., J Biol Chem 1999 : STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130 utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone
Burger et al., Oncogene 2005 (Cell Transformation, Neoplastic...) : In CXCR2 transfected NIH 3T3 cells and human microvascular endothelial cells ( HMEC ), which express the CXCR2 constitutively, STAT3 is phosphorylated upon stimulation with IL-8 ( CXCL8 )
Trevino et al., Angiogenesis 2006 (Adenocarcinoma...) : To ascertain whether Src mediated expression of IL-8 was dependent on STAT3 , we used stable clones expressing a dominant negative isoform of STAT3 that inhibits endogenous STAT3 phosphorylation and subsequent DNA binding and STAT3 mediated gene expression or a constitutively activated isoform of STAT3
Gharavi et al., J Biol Chem 2007 (Atherosclerosis) : Here we provide evidence that STAT3 activation by Ox-PAPC is dependent on JAK2 activation and that STAT3 activation regulates IL-8 transcription by Ox-PAPC in human EC
de la Iglesia et al., J Neurosci 2008 (Glioblastoma...) : Activated STAT3 occupies the endogenous IL8 promoter and directly represses IL8 transcription ... Importantly, IL8 repression mediates STAT3 inhibition of glioblastoma cell proliferation, invasiveness, and spreading on myelin ... These studies suggest that STAT3 activation or IL8 inhibition may have potential in patient tailored treatment of PTEN-deficient brain tumors
Oka et al., Exp Dermatol 2010 (Melanoma...) : These results indicate that the upregulation of IL-8 production is caused by constitutive STAT3 activation at the level of gene transcription in melanoma cells
Ozawa et al., Journal of ophthalmology 2011 : In innate chorioretinal inflammation, interleukin-6 family ligands induce STAT3 activation in photoreceptors, which causes UPS mediated excessive degradation of the visual substance, rhodopsin
Riebe et al., Anticancer Res 2011 (Carcinoma, Squamous Cell...) : Analyzing the effect of silencing of ERK1/2 MAPK revealed that this MAPK strongly influences IL-6 and IL-8 expression, but is not involved in either activation of STAT1 or STAT3
Zhang et al., J Cell Biochem 2012 (Helicobacter Infections...) : Although IL-8 and IL-6 levels correlated with STAT3 ( signal transducer and activator of transcription ) phosphorylation before and after H. pylori eradication in the gastric mucosa, only the blocking of IL-8 induced STAT3 activation using AG490 or STAT3 targeting RNA interference altered Hath1 expression