Gene interactions and pathways from curated databases and text-mining

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HBEGF — NOS2

Text-mined interactions from Literome

Lara-Marquez et al., Nitric Oxide 2002 : While cytokine exposure resulted in a significant increase in iNOS mRNA expression in these cells ( 109 plus minus 9 fold ), HB-EGF reduced iNOS expression by 5.7-fold ( P < 0.05 )
Mehta et al., J Immunol 2005 (MAP Kinase Signaling System) : Small interfering RNA of PI3K also reversed the inhibitory effect of HB-EGF on iNOS expression