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APOB — REN

Text-mined interactions from Literome

Galle et al., Kidney Int 1995 : Oxidized LDL and lipoprotein ( a ) stimulate renin release of juxtaglomerular cells ... We examined the effects of native and oxidized LDL and lipoprotein ( a) [Lp(a ) ] on renin release of juxtaglomerular cells ( JG cells ) prepared in primary culture from mouse kidneys ... Oxidized LDL increased renin release to 34 +/- 1 % and 43 +/- 1 % at 50 and 300 micrograms/ml, while oxidized Lp(a) stimulated renin release to 33 +/- 1 %, 42 +/- 1 %, and 71 +/- 2 % at 1, 10, and 30 micrograms/ml, respectively ... These data indicate that oxidized LDL and Lp(a) stimulate renin release in JG cells by a mechanism involving oxygen derived radicals
Wanner et al., Kidney Int Suppl 1997 (Disease Progression...) : In JG cells, both oxidized LDL and Lp(a) dose-dependently stimulated renin release