Gupta et al., Indian J Exp Biol 2010
:
In vitro effects of 5-hydroxytryptophan, indoleamines and leptin on arylalkylamine N-acetyltransferase ( AA-NAT ) activity in pineal organ of the fish, Clarias gariepinus ( Burchell, 1822 ) during different phases of the breeding cycle ... Further, in vitro effects of leptin on AA-NAT activity in the pineal organ were studied in fed and fasted fishes during summer and winter seasons ... However, leptin increased AA-NAT activity in a dose dependent manner only in the pineal organ of the fed fishes, but not of the fasted fishes irrespective of the seasons
Peliciari-Garcia et al., BioMed research international 2013
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In conclusion, leptin inhibition of pineal melatonin synthesis appears to be mediated by a reduction in AANAT activity and expression as well as by increased expression of Icer mRNA