Ladhani et al., Neoplasia (New York, N.Y.) 2011
(Neoplasm Invasiveness...) :
In vivo, knockdown of Rac1 and DOCK3 or overexpression of MT1-MMP was sufficient to reverse the inhibitory effect of PEDF on extravasation
Peng et al., PloS one 2012
(Nasopharyngeal Neoplasms...) :
The expressions of vascular endothelial growth factor ( VEGF ), matrix metalloproteinase-2 (MMP-2), MMP-9 , and MMP-14 decreased, while the level of pigment epithelium derived factor (PEDF) increased
Alcantara et al., Cell Physiol Biochem 2013
(Neoplasm Metastasis...) :
Regulation of MT1-MMP and MMP-2 by the Serpin PEDF : a Promising New Target for Metastatic Cancer ... Understanding the role of PEDF in the regulation of MT1-MMP and MMP-2 as it pertains to cancer control is important in order to understand whether and how such associations provide a novel target for cancer therapy