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GRB2 — HGF

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GRB2/GAB1 complex (MET-GRB2-GAB1-HGF) → SHP2 (PTPN11) (modification, collaborate) Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GRB2/GAB1 complex (MET-GRB2-GAB1-HGF) → HGF(dimer)/MET(dimer)/GRB2/GAB1/SHP2 complex (MET-GRB2-GAB1-PTPN11-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): SHP2 (PTPN11) → HGF(dimer)/MET(dimer)/GRB2/GAB1/SHP2 complex (MET-GRB2-GAB1-PTPN11-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GRB2/GAB1 complex (MET-GRB2-GAB1-HGF) → HGF(dimer)/MET(dimer) complex (MET-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Schaeper et al., Proc Natl Acad Sci U S A 2007, Nguyen et al., J Biol Chem 1997*
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GRB2/GAB1 complex (MET-GRB2-GAB1-HGF) → GRB2/GAB1 complex (GRB2-GAB1) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Schaeper et al., Proc Natl Acad Sci U S A 2007, Nguyen et al., J Biol Chem 1997*
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer) complex (MET-HGF) → GRB2/GAB1 complex (GRB2-GAB1) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Schaeper et al., Proc Natl Acad Sci U S A 2007, Nguyen et al., J Biol Chem 1997*
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): None → HGF(dimer)/MET(dimer)/GRB2/SOS1 complex (MET-GRB2-SOS1-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Ponzetto et al., Cell 1994, Graziani et al., J Biol Chem 1993
  Evidence: assay
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HRAS/GDP complex (HRAS) → HGF(dimer)/MET(dimer)/GRB2/SOS1 complex (MET-GRB2-SOS1-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Ponzetto et al., Cell 1994, Graziani et al., J Biol Chem 1993
  Evidence: assay
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): Erk1-2 (MAPK3/MAPK1) → HGF(dimer)/MET(dimer)/GRB2/GAB1/SHP2 complex (MET-GRB2-GAB1-PTPN11-HGF) (modification, collaborate)
  Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): None → HGF(dimer)/MET(dimer)/p52 SHC/GRB2/SOS1 complex (MET-SHC1-GRB2-SOS1-HGF) (modification, collaborate)
  Pelicci et al., Oncogene 1995
  Evidence: assay
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HRAS/GDP complex (HRAS) → HGF(dimer)/MET(dimer)/p52 SHC/GRB2/SOS1 complex (MET-SHC1-GRB2-SOS1-HGF) (modification, collaborate)
  Pelicci et al., Oncogene 1995
  Evidence: assay
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): GRB2 (GRB2) → HGF(dimer)/MET(dimer) complex (MET-HGF) (modification, collaborate)
  Parachoniak et al., J Biol Chem 2009
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): GRB2 (GRB2) → HGF(dimer)/MET(dimer)/GRB2 complex (MET-GRB2-HGF) (modification, collaborate)
  Parachoniak et al., J Biol Chem 2009
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer) complex (MET-HGF) → HGF(dimer)/MET(dimer)/GRB2 complex (MET-GRB2-HGF) (modification, collaborate)
  Parachoniak et al., J Biol Chem 2009
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/p52 SHC complex (MET-SHC1-HGF) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Pelicci et al., Oncogene 1995
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/p52 SHC complex (MET-SHC1-HGF) → HGF(dimer)/MET(dimer)/p52 SHC/GRB2/SOS1 complex (MET-SHC1-GRB2-SOS1-HGF) (modification, collaborate)
  Pelicci et al., Oncogene 1995
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): GRB2/SOS1 complex (GRB2-SOS1) → HGF(dimer)/MET(dimer)/p52 SHC/GRB2/SOS1 complex (MET-SHC1-GRB2-SOS1-HGF) (modification, collaborate)
  Pelicci et al., Oncogene 1995
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): EPS15 (EPS15) → HGF(dimer)/MET(dimer)/GRB2 complex (MET-GRB2-HGF) (modification, collaborate)
  Parachoniak et al., J Biol Chem 2009
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): EPS15 (EPS15) → HGF(dimer)/MET(dimer)/GRB2/EPS15 complex (MET-GRB2-EPS15-HGF) (modification, collaborate)
  Parachoniak et al., J Biol Chem 2009
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GRB2 complex (MET-GRB2-HGF) → HGF(dimer)/MET(dimer)/GRB2/EPS15 complex (MET-GRB2-EPS15-HGF) (modification, collaborate)
  Parachoniak et al., J Biol Chem 2009
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GRB2/SOS1 complex (MET-GRB2-SOS1-HGF) → HGF(dimer)/MET(dimer) complex (MET-HGF) (modification, collaborate)
  Higuchi et al., Mol Cell Biol 2004, Ponzetto et al., Cell 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GRB2/SOS1 complex (MET-GRB2-SOS1-HGF) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Higuchi et al., Mol Cell Biol 2004, Ponzetto et al., Cell 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer) complex (MET-HGF) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Higuchi et al., Mol Cell Biol 2004, Ponzetto et al., Cell 1994
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: GRB2 — HGF (interaction, mapped from grid bind)
• STRING interaction: GRB2 — HGF (interaction, mapped from grid bind)
• STRING interaction: HGF — GRB2 (interaction, mapped from mint intact)
• STRING interaction: HGF — GRB2 (interaction, mapped from mint intact)

Text-mined interactions from Literome

Leibowitz-Amit et al., Cancer Res 2006 (Breast Neoplasms) : The exogenous induction of Mimp at levels similar to its endogenous induction by HGF/SF increases the level of the Met protein and its phosphorylation by HGF/SF but reduces the levels of Shc and prevents the HGF/SF induced tyrosine phosphorylation of Grb2 and Shc
Chen et al., J Biol Chem 1998 : Finally, we demonstrated that HGF stimulates the association of FAK with Grb2 in vitro and in intact cells and provided evidence that FAK might contribute to the activation of mitogen activated protein kinase through Ras in HGF signaling by functioning as an adapter molecule