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ITGA1 — ITGA4

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of ITGA1-ITGA4-PRKCA → PRKCA (increases, ITGA1/ITGA4/PRKCA Activity) Podar et al., J Biol Chem 2002*
  Evidence: PKCa Associates with b1 Integrin and CADTK...We therefore next determined whether PKCa and b1 integrin are associated in MM cells. Constitutive complex formation between these two proteins was demonstrated by co-immunoprecipitation...Upon activation and translocation, conventional PKCs associate with proteins of the transmembrane-4 superfamily (TM4SF or tetraspans) linking PKC to several subsets of integrins (38) including a4b1 (39) and a5b1...the integrin-TM4SF-PKC complex formation results in ...
• KEGG Focal adhesion: ACTN1/ACTN2/ACTN3/ACTN4 → Complex of 21 proteins (protein-protein, binding/association)
• KEGG Focal adhesion: FLNA/FLNB/FLNC → Complex of 21 proteins (protein-protein, binding/association)
• KEGG Focal adhesion: TLN1/TLN2 → Complex of 21 proteins (protein-protein, binding/association)
• KEGG Focal adhesion: PXN → Complex of 21 proteins (protein-protein, binding/association)
• KEGG Focal adhesion: VASP → Complex of 21 proteins (protein-protein, binding/association)
• KEGG Focal adhesion: PARVA/PARVB/PARVG → Complex of 21 proteins (protein-protein, binding/association)
• KEGG Focal adhesion: CHAD/COL11A1/COL11A2/COL1A1/COL1A2/COL2A1/COL3A1/COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/COL5A1/COL5A2/COL5A3/COL6A1/COL6A2/COL6A3/COL6A6/COMP/FN1/IBSP/LAMA1/LAMA2/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/LAMB4/LAMC1/LAMC2/LAMC3/RELN/SPP1/THBS1/THBS2/THBS3/THBS4/TNC/TNN/TNR/TNXB/VTN/VWF → Complex of 21 proteins (protein-protein, activation)
• KEGG Dilated cardiomyopathy: Complex of 21 proteins → ACTB/ACTG1 (protein-protein, binding/association)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• Gene Ontology Complexes integrin complex: integrin complex complex (ITGAX-ITGB1-ITGB2-ITGB5-ITGB7-ITGB6-ITGA9-ITGA2B-ITGA2-ITGA3-ITGA4-ITGAV-ITGA10-ITGA8-ITGA6-ITGB8-ITGA1-ITGA11-ITGAD-ITGAE) Lehnert et al., Genomics 1999, Camenisch et al., J Biol Chem 2002, Antonov et al., Am J Pathol 2004, Moyle et al., J Biol Chem 1991, Kang et al., The journal of physical chemistry. B 2010, Schnapp et al., J Cell Sci 1995, Shaw et al., J Biol Chem 1994, Palmer et al., J Cell Biol 1993, Briesewitz et al., J Biol Chem 1993, Shang et al., J Immunol 1998, Camper et al., J Biol Chem 1998