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ERBB3 — RAC1

Text-mined interactions from Literome

Yang et al., Mol Cell Biol 2006 (Breast Neoplasms) : Using specific ErbB receptor inhibitors and depletion of receptors by RNA interference ( RNAi ), we established that, surprisingly, activation of Rac by HRG is mediated not only by ErbB3 and ErbB2 but also by transactivation of EGFR, and it is independent of ErbB4
Kawano et al., J Biol Chem 2009 : ErbB2 and ErbB3 , members of the EGF receptor/ErbB family, form a heterodimer upon binding of a ligand, inducing the activation of Rac small G protein and Akt protein kinase for cell movement and survival, respectively ... This interaction reduced the ligand induced, ErbB2 catalyzed tyrosine phosphorylation of ErbB3 and inhibited the consequent ErbB3 mediated activation of Rac and Akt, resulting in the inhibition of cancer cell movement and survival