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JAK1 — PTK2B

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PTK2B → JAK1 (increases, JAK1 Activity, PTK2B Activity) Shi et al., J Biol Chem 2004*
  Evidence: Pyk2 is a member of the focal adhesion kinase family and can be activated by c-Src, epidermal growth factor receptor (EGFR), Janus kinase 1, tyrosine kinases, and G-protein-coupled receptor signaling.
• BioCarta il-7 signal transduction: IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3) → PYK2 (PTK2B) (modification, activates)
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/PYK2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-PTK2B) (modification, collaborate)
  Miyazaki et al., Genes Dev 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → PYK2 (PTK2B) (modification, collaborate) Miyazaki et al., Genes Dev 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/PYK2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-PTK2B) → PYK2 (PTK2B) (modification, collaborate) Miyazaki et al., Genes Dev 1998
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: JAK1 — PTK2B (physical association, affinity chromatography technology) Benbernou et al., J Biol Chem 2000*
• IRef Hprd Interaction: Complex of IL7R-JAK1-PTK2B-JAK1-IL7R-PTK2B-PTK2B-IL7R-JAK1 (in vivo) Benbernou et al., J Biol Chem 2000*
• IRef Hprd Interaction: JAK1 — PTK2B (in vivo) Benbernou et al., J Biol Chem 2000*
• IRef Hprd Interaction: JAK1 — PTK2B (in vitro) Benbernou et al., J Biol Chem 2000*
• IRef Ophid Interaction: JAK1 — PTK2B (aggregation, confirmational text mining) Benbernou et al., J Biol Chem 2000*
• IRef Ophid Interaction: JAK1 — PTK2B (aggregation, interologs mapping) Brown et al., Bioinformatics 2005