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CXADR — EPHB2

Text-mined interactions from Literome

Hoff et al., Neoplasia (New York, N.Y.) 1999 (Cell Transformation, Neoplastic...) : The mutant CaR causes a calcium dependent activation of the extracellular signal regulated protein kinase ( ERK ) 1/2 and Jun-N-terminal kinase/stress activated ( JNK/ SAPK ) pathways, but not P38 MAP kinase
Handlogten et al., J Biol Chem 2001 : Chemical inhibitors of the ERK activator, MEK, and a dominant negative MEK, MEK ( K97R ), had no effect on CaR stimulated cPLA(2) activity but inhibited CaR stimulated ERK activity
Tfelt-Hansen et al., Endocrinology 2004 (Hypercalcemia...) : Taken together, our data show that activation of PI3K and p38 MAPK but not of MEK1/ERK by the CaR promotes proliferation of H-500 cells as well as affords protection against apoptosis
Holstein et al., J Biol Chem 2004 (MAP Kinase Signaling System) : The calcium sensing receptor (CaR) recently has been shown to activate MAP kinase (ERK1/2) in various cell types as well as in heterologous expression systems
Zhang et al., J Biol Chem 2005 (MAP Kinase Signaling System) : CaR mediated ERK phosphorylation can be localized to a predicted alpha-helix proximal to the membrane, which has been shown to be important for G protein mediated signaling ( residues 868-879 )
Davies et al., Am J Physiol Cell Physiol 2006 : In contrast, CaR induced cytoskeletal changes were not induced by the aromatic amino acids, treatments that also failed to potentiate CaR induced ERK activation despite inducing Ca2+ ( i ) mobilization
Lee et al., Biochem J 2007 : The impact of amino acids on CaR stimulated ERK1/2 , however, has not been determined
Reyes-Ibarra et al., Mol Endocrinol 2007 (Calcium Signaling) : Interestingly, this Rab11a dominant negative mutant does not interfere with CaR dependent activation of ERK 1/2, suggesting that ERK signaling is not sufficient to promote PTHrP secretion downstream of CaR