Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
Complex of ESR1-KAT2B
→
CCND1
(increases)
Evidence: Cyclin D1, a protein frequently overexpressed in breast cancer, has been shown to activate unliganded ER through recruiting p160 coactivators and p/CAF [52-55]. The calcium binding protein calmodulin and the activating enzyme of NEDD8, Uba3, both regulate ER activity by modulating the steady-state level of the receptor [56,57].
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *