◀ Back to JUN
JUN — SERPINE1
Text-mined interactions from Literome
Dichtl et al., Arterioscler Thromb Vasc Biol 1999
:
Pretreatment of LDL with the antioxidant probucol decreased expression of oxidized LDL and
PAI-1 immunoreactivity and
activator protein-1 induction in the aorta but did not affect expression of apolipoprotein B immunoreactivity
Ahn et al., Diabetologia 2001
:
We evaluated the
role of
AP-1 in
PAI-1 gene expression in human vascular smooth muscle cells under high D-glucose and Ang II stimulation using a double stranded cis-element AP-1 oligodeoxynucleotide ( decoy ODN ) ... These data indicate an important
role for
AP-1 in
PAI-1 expression
Andrew et al., Am J Physiol Lung Cell Mol Physiol 2001
:
Addition of nickel to BEAS-2B human airway epithelial cells stimulated intracellular oxidation,
induced c-Jun and c-Fos mRNA levels, increased phospho- and total c-Jun protein levels, and elevated
PAI-1 mRNA levels over a 24-h time course ... These data indicated that nickel activated AP-1 through an oxidant independent pathway and that basal
AP-1 is
necessary for nickel induced expression of
PAI-1
Omura et al., J Mol Cell Cardiol 2005
:
Dominant negative mutants of JNK, ASK-1 and
c-Jun significantly
inhibited PAI-1 mRNA expression and protein synthesis in both cardiomyocytes and fibroblasts, whereas a dominant negative mutant of p38MAPK did not change this expression
Zhou et al., J Cell Biochem 2005
:
We found that the
c-Jun N-terminal kinase (JNK) inhibitor, SP600125,
increased the inhibitory effects of SalB on TNF-alpha induced
PAI-1 secretion, whereas the nuclear factor-kappaB (NF-kappaB) inhibitor, emodin, and the extracellular signal regulated kinase ( ERK ) inhibitor, PD98059, did not
Deng et al., Mol Biol Cell 2006
:
MEKK1 ablation or down-regulation by interfering RNA significantly delays skin wound closure and impairs activation of
Jun NH2-terminal kinases,
induction of plasminogen activator inhibitor
(PAI)-1 , and restoration of cell-cell junctions of the wounded epidermis
Vayalil et al., Am J Physiol Lung Cell Mol Physiol 2007
:
Decoy oligonucleotides ( ODN ) studies further demonstrate that
AP-1 , SP-1, and Smad ODNs abrogate the inhibitory effect of GSH on TGF-beta induced PAI-1 promoter activity and
inhibit TGF-beta induced expression of endogenous
PAI-1
Geh et al., Proc Natl Acad Sci U S A 2011
(MAP Kinase Signaling System) :
The second network is initiated by the enzymatic activity of MAP3K1, which phosphorylates and activates a JNK-c-Jun module, leading to
AP-1 transactivation and
induction of its downstream genes, such as
Pai-1
Sundqvist et al., Oncogene 2013
(Breast Neoplasms...) :
Finally, chromatin immunoprecipitations showed that
c-Jun , JunB and Fra1, but not c-Fos, are
required for TGFß induced binding of Smad2/3 to the mmp-10 and
pai-1 promoters
Arts et al., Eur J Biochem 1996
:
An essential
role of
c-Jun and c-Fos in basal and PMA stimulated transcription of the
PAI-1 gene is demonstrated by our finding that antisense c-jun and c-fos oligodeoxynucleotides both strongly reduced basal and PMA stimulated PAI-1 synthesis
Mucsi et al., Biochem Biophys Res Commun 1997
:
Activation of the
PAI-1 promoter by TGF-beta or prostaglandin F2 alpha, and transactivation by
c-Jun or JunB were not inhibited by dominant negative Smad3, supporting the specificity of this mutant
Arts et al., Arterioscler Thromb Vasc Biol 1999
(Carcinoma, Hepatocellular...) :
On the
role of
c-Jun in the induction of
PAI-1 gene expression by phorbol ester, serum, and IL-1alpha in HepG2 cells