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EGFR — HSP90AA1

Pathways - manually collected, often from reviews:

• NCI Pathway Database ErbB receptor signaling network: HSP90 (dimer) complex (HSP90AA1) → EGFR/ErbB2/EGF complex (EGFR-ERBB2-EGF) (modification, collaborate)
  Citri et al., EMBO Rep 2004, Hazan et al., Cell Growth Differ 1990, Stern et al., EMBO J 1988*, Qian et al., Proc Natl Acad Sci U S A 1994, Graus-Porta et al., EMBO J 1997
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: HSP90 (dimer) complex (HSP90AA1) → EGFR (EGFR) (modification, collaborate) Citri et al., EMBO Rep 2004, Hazan et al., Cell Growth Differ 1990, Stern et al., EMBO J 1988*, Qian et al., Proc Natl Acad Sci U S A 1994, Graus-Porta et al., EMBO J 1997
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: ErbB2/ErbB2/HSP90 (dimer) complex (ERBB2-HSP90AA1) → EGFR/ErbB2/EGF complex (EGFR-ERBB2-EGF) (modification, collaborate)
  Citri et al., EMBO Rep 2004, Hazan et al., Cell Growth Differ 1990, Stern et al., EMBO J 1988*, Qian et al., Proc Natl Acad Sci U S A 1994, Graus-Porta et al., EMBO J 1997
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: ErbB2/ErbB2/HSP90 (dimer) complex (ERBB2-HSP90AA1) → EGFR (EGFR) (modification, collaborate) Citri et al., EMBO Rep 2004, Hazan et al., Cell Growth Differ 1990, Stern et al., EMBO J 1988*, Qian et al., Proc Natl Acad Sci U S A 1994, Graus-Porta et al., EMBO J 1997
  Evidence: assay, physical interaction
• Reactome Reaction: EGFR → HSP90AA1 (reaction) Borg et al., Nat Cell Biol 2000, Xu et al., J Biol Chem 2001, Lavictoire et al., J Biol Chem 2003*, Roe et al., Cell 2004*, Sordella et al., Science 2004, Citri et al., EMBO Rep 2004, Xu et al., Nature structural & molecular biology 2005, Shimamura et al., Cancer Res 2005, Greulich et al., PLoS Med 2005, Zhang et al., Cell 2006, Yang et al., Cancer Res 2006, Wahl et al., J Biol Chem 1990, Han et al., Cancer Biol Ther 2006, Li et al., Cell Signal 2007, Lee et al., PLoS Med 2006, Yun et al., Cancer Cell 2007*, Huang et al., Proc Natl Acad Sci U S A 2007, Padrón et al., Cancer Res 2007, Wada et al., Cell 1990, Meisenhelder et al., Cell 1989, Karunagaran et al., EMBO J 1996, Pinkas-Kramarski et al., EMBO J 1996
• Reactome Reaction: EGFR → HSP90AA1 (indirect_complex) Lavictoire et al., J Biol Chem 2003*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: EGFR — HSP90AA1 Lavictoire et al., J Biol Chem 2003*
• IRef Bind_translation Interaction: EGFR — HSP90AA1 (coimmunoprecipitation) Lavictoire et al., J Biol Chem 2003*
• IRef Biogrid Interaction: EGFR — HSP90AA1 (physical association, affinity chromatography technology) Citri et al., EMBO J 2002*
• IRef Biogrid Interaction: EGFR — HSP90AA1 (physical association, affinity chromatography technology) Foerster et al., Proteomics 2013
• IRef Biogrid Interaction: EGFR — HSP90AA1 (physical association, affinity chromatography technology) Yang et al., Cancer Res 2006
• IRef Biogrid Interaction: EGFR — HSP90AA1 (physical association, affinity chromatography technology) Shimamura et al., Cancer Res 2005
• IRef Biogrid Interaction: EGFR — HSP90AA1 (physical association, affinity chromatography technology) Lavictoire et al., J Biol Chem 2003*
• IRef Intact Interaction: EGFR — HSP90AA1 (physical association, ubiquitin reconstruction) Deribe et al., Science signaling 2009
• IRef Intact Interaction: Complex of 12 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 29 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 40 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 64 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 26 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Ophid Interaction: EGFR — HSP90AA1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Xu et al., Br J Cancer 2007 (Carcinoma, Non-Small-Cell Lung...) : The mature epidermal growth factor receptor (EGFR) neither associates with nor requires the molecular chaperone heat-shock protein 90 (Hsp90)
Sawai et al., Cancer Res 2008 (Carcinoma, Non-Small-Cell Lung...) : Hsp90 inhibitors, such as 17-allylamino-17-demethoxygeldanamycin ( 17-AAG ), induce the degradation of EGFR and other Hsp90 interacting proteins and may thus have utility in tumors dependent upon sensitive Hsp90 clients
Adachi et al., Oncol Rep 2010 (Pancreatic Neoplasms) : These results strongly suggest that EGFR phosphorylation at Ser1046/7 via activation of p38 MAPK induced by HSP90 inhibitors plays a pivotal role in EGFR desensitization in human pancreatic cancer cells
El Hamidieh et al., PloS one 2012 (Breast Neoplasms...) : Finally, we show that functional inhibition of surface HSP90 using mAb 4C5, a cell impermeable monoclonal antibody against this protein, leads not only to disruption of the Cdc37/HSP90 complex but also to inhibition of the Cdc37/ErbB receptors complexes
Ahsan et al., Neoplasia (New York, N.Y.) 2012 (Head and Neck Neoplasms...) : Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors ... Further, the HSP90 inhibitors geldanamycin ( GA ) and AT13387 cause a decrease in WT-EGFR in cultured head and neck cancer cells