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ANGPT2 — HRAS
Text-mined interactions from Literome
Gendron et al., Mol Endocrinol 1999
:
Stimulation of NG108-15 cells with
Ang II induced a decrease in GTP bound
p21ras but a sustained increase in the activity of p42mapk and p44mapk as well as neurite outgrowth
Sadoshima et al., EMBO J 1996
:
The
p21 ras activation by
Ang II is mediated by an increase in the guanine nucleotide exchange activity, but not by an inhibition of the GTPase activating protein
Eguchi et al., J Biol Chem 1996
:
These data suggest that
Ang II-induced MAPK activation through the Ang II type 1 receptor could be
mediated by
p21(ras)activation through a currently unidentified tyrosine kinase that lies downstream of Gq-coupled Ca2+/calmodulin signals
Li et al., EMBO J 1998
:
In control cells,
Ang II and TPA produced minimal
increases in
Ras-GTP level and Raf kinase activity ... In PKC depleted cells,
Ang II increased
Ras-GTP level and activated Raf and ERK in a Ras dependent manner
Jiao et al., Proc Natl Acad Sci U S A 1998
:
The aim of this study was to determine whether arachidonic acid mediates
Ang II 's
effect on
p21ras and if so, to ascertain the signaling mechanism ( s ) ... Moreover,
Ang II and arachidonic acid
induced an association between
p21ras and Shc