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LEP — TGFB1

Text-mined interactions from Literome

Gottschling-Zeller et al., Eur J Endocrinol 1999 : The aim of this study was to characterize the role of tumor necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta1 in depot-specific secretion of leptin from cultured human adipocytes ... We measured the leptin concentrations in the culture medium of omental and subcutaneous abdominal adipocytes taken from severely obese individuals and kept in suspension culture, and studied the effect of TNF-alpha and TGF-beta1 on leptin release
Han et al., Kidney Int 2001 (Diabetes Mellitus) : In db/db mesangial cells, leptin increased 2-deoxy-D-glucose ( 2DOG ) uptake dose dependently and stimulated gene expression of TGF-beta type II receptor ( TbetaRII ) and alpha1 ( I ) collagen, but not TGF-beta1
Ikejima et al., Hepatology 2001 (Carbon Tetrachloride Poisoning...) : It is postulated that the increase in systemic leptin levels enhances up-regulation of TGF-beta1 , leading to activation of stellate cells, thereby augmenting the fibrogenic response in the liver
Wolf et al., Am J Kidney Dis 2002 (Body Weight...) : In glomerular endothelial cells, leptin stimulates cellular proliferation, transforming growth factor-beta1 ( TGF-beta1 ) synthesis, and type IV collagen production ... Conversely, in mesangial cells, leptin upregulates synthesis of the TGF-beta type II receptor, but not TGF-beta1 , and stimulates glucose transport and type I collagen production through signal transduction pathways involving phosphatidylinositol-3-kinase
Leclercq et al., J Hepatol 2002 (Chronic Disease...) : We showed that leptin deficiency did not alter hepatic TNF regulation but that leptin is necessary for induction of bioactive transforming growth factor beta 1 ( TGFbeta1 ) protein in the context of chronic liver injury
Tang et al., Biochem Biophys Res Commun 2003 : These effects of leptin on fibrogenesis may be mediated by TGFbeta1 , since leptin increases the TGFbeta type II receptor and augments the effect of TGFbeta1 on collagen production by stellate cells ... Leptin did not increase significantly the binding of proteins to two TGFbeta1 responsive elements in the human alpha1 ( I ) collagen promoter
Frankenberry et al., Am J Surg 2004 (Neovascularization, Pathologic...) : Leptin significantly induced expression of vascular endothelial growth factor ( VEGF ), transforming growth factor-beta1 ( TGF-beta1 ), and basic fibroblast growth factor (bFGF) in DU145 and PC-3 cells ... Leptin significantly induced expression of vascular endothelial growth factor ( VEGF ), transforming growth factor-beta1 ( TGF-beta1 ), and basic fibroblast growth factor (bFGF) in DU145 and PC-3 cells
Simons et al., Cytokine 2005 : However, TNF-alpha, IL-1beta, and TGF-beta1 stimulated leptin production from preadipocytes in the absence of mature adipocytes ( 20.6+/-5.4 ng/ml, 100.8+/-18.2 ng/ml, and 5.4+/-0.4 ng/ml, respectively, compared to 6.6+/-0.8 ng/ml in control adipocyte cultures on day 21 ; n=4 )
Leung et al., Kidney Int 2006 : The effect of leptin on the production of transforming growth factor-beta ( TGF-beta ) by mesothelial cells in the presence or absence of high glucose was determined using in vitro culture model of human peritoneal mesothelial cells and adipocytes
Balasubramaniyan et al., Cytokine 2007 : The aim of our present work was to study the effect of exogenous leptin and/or ethanol on the secretion of TNF-alpha, IL-6 and TGF-beta1 both in vivo and in vitro
Mutabaruka et al., Arthritis Res Ther 2010 (Osteoarthritis) : These results suggest that abnormal production of leptin by OA Ob could be responsible , in part, for the elevated levels of ALP, OC, collagen type 1 and TGF-beta1 observed in these cells compared to normal