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CCL2 — STAT1

Text-mined interactions from Literome

Lee et al., Am J Physiol Heart Circ Physiol 2003 : The role of STAT1 in the regulation of the IL-4 induced MCP-1 gene expression was further confirmed in HUVEC transfected with a reporter construct of the MCP-1 promoter with a mutated STAT1 binding site ... These results demonstrate that IL-4 dependent MCP-1 induction in HUVEC is mediated by redox regulated STAT1 activation
Harvey et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis) : The IFN-gamma induced activity of the MCP-1 gene promoter and an artificial promoter containing STAT1 responsive elements was inhibited by expression of dominant negative forms of JAK-1 and -2, STAT1 , CK2, and AKT
Kok et al., Arthritis Rheum 2009 (Arthritis) : Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling : an implication for the pathogenesis of arthritis ... In U2OS cells, STAT-1 and STAT-3 were involved in OSM stimulated CCL2 expression, and both the phosphatidylinositol 3-kinase/Akt and MEK/ERK pathways were implicated in the activation of these STATs ... STAT-1 and STAT-3 modulated the expression of c-Fos and directly transactivated the CCL2 promoter
Strassheim et al., J Immunol 2009 : We found that activation of STAT1 was critical for IFN-gamma induced MCP-1 production and demonstrated that iloprost inhibited STAT1 activation by several actions as follows : 1 ) iloprost inhibited the phosphorylation of STAT1-S727 in the transactivation domain, thereby reducing recruitment of the histone acetylase and coactivator CBP/p300 to STAT1 ; 2 ) iloprost selectively inhibited activation of JAK2 but not JAK1, both responsible for activation of STAT1 via phosphorylation of STAT1-Y701, resulting in reduced nuclear recruitment and activation of STAT1 ; and 3 ) SOCS-1, which normally terminates IFN-gamma signaling, was not involved in iloprost mediated inhibition of STAT1, indicating divergence from the classical pathway for terminating IFN-gamma signaling
Tang et al., Am J Nephrol 2010 (Diabetes Mellitus, Type 2...) : In addition, Ros but not metformin attenuated renal cortical expression of CCL2 , MIP-2, and ICAM-1 and inhibited p-STAT1 signal activation