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NPY — POMC
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Vázquez-Martínez et al., Neuroendocrinology 2001
:
NPY inhibited
POMC transcript accumulation and tended to reduce alpha-MSH secretion in HD cells, yet these effects were less pronounced than those evoked in LD cells
Sindelar et al., Diabetes 2002
(Body Weight...) :
We conclude that
NPY is
required for both the increase of food intake and the decrease of hypothalamic
POMC gene expression induced by uncontrolled diabetes
Rousseau et al., Endocrinology 2002
(Body Weight) :
On SD, hypothalamic
neuropeptide Y , agouti related peptide, and cocaine- and amphetamine regulated transcript gene expression in the arcuate nucleus did not exhibit significant changes, and despite SD-induced fat loss, the catabolic peptide
proopiomelanocortin was
down-regulated
Sainsbury et al., Diabetes 2002
(Diabetes Mellitus, Type 2...) :
Y2 deletion in ob/ob mice significantly
increased the hypothalamic
POMC mRNA expression, with no effect on
NPY , AgRP, or CART expression
Verburg-van Kemenade et al., Peptides 1987
:
During superfusion of neurointermediate lobe tissue, synthetic
NPY induces a rapid, powerful and dose dependent inhibition of in vitro release of MSH, endorphin and other
proopiomelanocortin (POMC) derived peptides
Garcia de Yebenes et al., Brain Res 1995
:
Regulation of
proopiomelanocortin gene expression by
neuropeptide Y in the rat arcuate nucleus ... In order to determine whether NPY could influence POMC neuronal activity, we have studied the
effects of
NPY and some NPY analogs on
POMC gene expression using quantitative in situ hybridization