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Bouchard et al., EMBO J 2004
(Cell Transformation, Neoplastic) :
Myc induced proliferation and transformation require Akt mediated phosphorylation of FoxO proteins
Gomis et al., Cancer Cell 2006
(Breast Neoplasms...) :
We found the transcription factor C/EBPbeta to be essential for TGFbeta induction of the cell cycle inhibitor p15INK4b by a FoxO-Smad complex and repression of c-MYC by an E2F4/5-Smad complex in human epithelial cells
Bouchard et al., Genes Dev 2007
(Lymphoma) :
Moreover, constitutive Myc signaling induces a marked increase in nuclear FoxO levels and stimulates binding of FoxO proteins to the Arf locus