Zhou et al., J Biol Chem 2007
:
In contrast, Trx2 attenuated activities of Akt , p70S6K, and eIF-4E and provoked an increase in mitochondrial reactive oxygen species production
Chen et al., Am J Physiol Lung Cell Mol Physiol 2013
(Anoxia) :
Both small interfering RNA mediated knockdown and pharmacological Trx1 inhibition attenuated hypoxia induced PASMC proliferation, HIF activation, and Akt activation ... Thus, our findings indicate that Trx1 contributes to hypoxia induced PASMC proliferation by modulating HIF activation and subsequent PI3K-Akt activation