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FAS — IL8
Text-mined interactions from Literome
Hagimoto et al., Am J Respir Cell Mol Biol 1999
:
Induction of
interleukin-8 secretion and apoptosis in bronchiolar epithelial cells by
Fas ligation ... In this study we investigated whether
Fas ligation
induces IL-8 secretion in addition to apoptosis in bronchiolar epithelial cells in vitro
Verhagen et al., Cytokine 2001
(Colonic Neoplasms) :
TNF and
CD95 promote
IL-8 gene transactivation via independent elements in colon carcinoma cells ... While the IL-8 promotor elements activated by TNF are well characterised, those responsible for
induction of
IL-8 by
CD95 are unknown ... Nevertheless,
IL-8 induction by
CD95 resulted primarily from increased transcription and not from an increase in IL-8 mRNA stability ... These results suggest that promoter elements/enhancers involved in
CD95 mediated
IL-8 induction are distinct from those used by TNF and not contained within the 1.6 kb region immediately upstream of the initiation codon
Shimada et al., J Gastroenterol Hepatol 2001
(Adenocarcinoma...) :
The pretreatment with interferon (IFN)-gamma markedly enhanced the effects of Fas Ag stimulation ; IFN-gamma pretreatment and
Fas Ag stimulation synergistically
induced not only apoptosis but also
IL-8 and MCP-1 secretion
Saas et al., Neuroreport 2002
(Encephalitis) :
It was previously shown that astrocytes are resistant to Fas mediated death, responding to
Fas triggering by
interleukin-8 production
Shin et al., Yonsei Med J 2002
(Carcinoma, Hepatocellular...) :
Conclusively, TGF-beta2,
IL-8 and MCP-1 were overexpressed in HBV associated hepatoma cells, and the expressions of chemokines were not
increased by
Fas ligation in human hepatoma cells
O'Brien et al., Ann N Y Acad Sci 2002
(MAP Kinase Signaling System) :
Activation of the p38 MAPK and ERK1/2 pathways is required for
Fas induced
IL-8 production in colonic epithelial cells ... This paper aims to examine the contribution of all three of the MAP kinase signaling pathways to
Fas induced
IL-8 up-regulation in HT29 colon epithelial cells
Yamaoka-Tojo et al., Coron Artery Dis 2003
:
Fas neutralizing agent ( Fas-Fc ) suppressed the
Fas mediated secretions of
IL-8 and MCP-1 ( P < 0.01 ) both as well as the Fas mediated apoptosis ... On the other hand, whereas Z-IETD-FMK suppressed apoptosis, the inhibitor enhanced the
Fas mediated secretions of both
IL-8 and MCP-1 beyond the value of the Fas stimulation alone ( P < 0.01 ), suggesting an enhanced signalling for the chemokine expression
Brat et al., Neuro Oncol 2005
(Brain Neoplasms...) :
In addition to hypoxia/anoxia stimulation, increased
IL-8 in gliomas occurs in
response to
Fas ligation, death receptor activation, cytosolic Ca ( 2+ ), TNF-alpha, IL-1, and other cytokines and various cellular stresses
Koshika et al., Inflamm Res 2006
(Inflammation...) :
Both
Fas and A23187
caused significant
IL-8 expression and cell death in A549 cells
Scheller et al., J Neural Transm Suppl 2006
:
Moreover,
CD95 triggered expression of IL-4 and
IL-8 when caspase activity was inhibited, but not in the absence of ZVAD
Chang et al., Experimental biology and medicine (Maywood, N.J.) 2009
:
Taken together, the production of
IL-8 by SPE B in A549 cells is
mediated by
Fas , and followed by the activation of FADD, caspase 8, MEKK1, ERK and NF-kappaB
Cullen et al., Mol Cell 2013
:
Fas induced production of MCP-1 and
IL-8 promoted chemotaxis of phagocytes toward apoptotic cells, suggesting that these factors serve as `` find-me '' signals in this context
Cesaratto et al., PloS one 2013
:
E3330 treatment prevented the functional activation of NF-?B via the alteration of APE1 subcellular trafficking and reduced IL-6 and
IL-8 expression
induced by TNF-a and
FAs accumulation through blockage of the redox mediated activation of NF-?B
Abreu-Martin et al., J Immunol 1995
(Second Messenger Systems) :
The experiments presented here demonstrate that
Fas Ag ligation alone
led to production of
IL-8 by colonic epithelial cells and represented another function mediated by Fas Ag in addition to apoptosis ... This study shows that the pathways leading to cell death and
IL-8 production in
response to
Fas Ag ligation and TNF-alpha were similar with regard to their requirements for new gene expression, protein synthesis, and protein kinase activity
Sekine et al., Biochem Biophys Res Commun 1996
(Arthritis, Rheumatoid) :
Fas mediated stimulation
induces IL-8 secretion by rheumatoid arthritis synoviocytes independently of CPP32 mediated apoptosis
Yamada et al., Diabetologia 1996
(Autoimmune Diseases...) :
Mouse islet cell lysis mediated by
interleukin-1 induced
Fas