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IL12B — SPP1

Text-mined interactions from Literome

O'Regan et al., J Leukoc Biol 2000 : These findings suggest a functional role for osteopontin in early Th1 responses, namely regulation of T cell dependent IL-12 production
Koguchi et al., Infect Immun 2002 (AIDS-Related Opportunistic Infections) : We investigated the role of osteopontin (OPN) in interleukin-12 (IL-12) production from peripheral blood mononuclear cells ( PBMCs ) stimulated with Penicillium marneffei ... Furthermore, native OPN induced a profound level of synthesis of IL-12 from noninfected PBMCs ... Our results demonstrated that OPN secreted from monocytes is involved in the production of IL-12 from PBMCs after stimulation with P. marneffei and that OPN production is regulated by GM-CSF
Koguchi et al., Am J Respir Crit Care Med 2003 (Sarcoidosis, Pulmonary...) : In vitro experiments showed that OPN production by peripheral blood mononuclear cells infected with Mycobacterium bovis bacillus Calmette-Guérin preceded the synthesis of IL-12 and interferon-gamma and that the neutralizing anti-OPN monoclonal antibody significantly reduced the production of IL-12 and interferon-gamma
Morimoto et al., Int Immunol 2004 (Drug-Induced Liver Injury...) : Second, OPN deficiency resulted in the reduction of IL-12 and IFN-gamma production at early stages
Renkl et al., Blood 2005 : OPN induces their Th1 promoting tumor necrosis factor alpha (TNF-alpha) and interleukin-12 (IL-12) secretion, and enhances their allostimulatory capacity
Sato et al., Gut 2005 (Colitis, Ulcerative...) : Recent studies have shown that OPN plays an important role in lymphocyte migration, granuloma formation, and interleukin 12 (IL-12) production ... OPN induced production of IL-12 from LPMC in CD but not in normal controls or UC