◀ Back to YY1

SP1 — YY1

Pathways - manually collected, often from reviews:

• FastForward regulation: SP1 → YY1 (transcriptional regulation, unknown)
  Evidence: DNABINDING
• FastForward regulation: YY1 → SP1 (transcriptional regulation, unknown) Xi et al., Genome Res 2007
  Evidence: DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: YY1 — SP1 Lee et al., Proc Natl Acad Sci U S A 1993*
• IRef Bind_translation Interaction: YY1 — SP1 (experimental interaction detection) Lee et al., Proc Natl Acad Sci U S A 1993*
• IRef Bind_translation Interaction: YY1 — SP1 (affinity chromatography technology) Lee et al., Proc Natl Acad Sci U S A 1993*
• IRef Bind_translation Interaction: YY1 — SP1 (electrophoretic mobility shift assay) Lee et al., Proc Natl Acad Sci U S A 1993*
• IRef Biogrid Interaction: YY1 — SP1 (physical association, affinity chromatography technology) Qiao et al., Free Radic Biol Med 2011*
• IRef Biogrid Interaction: YY1 — SP1 (direct interaction, pull down) Lee et al., Proc Natl Acad Sci U S A 1993*
• IRef Biogrid Interaction: YY1 — SP1 (physical association, affinity chromatography technology) Lee et al., Proc Natl Acad Sci U S A 1993*
• IRef Biogrid Interaction: YY1 — SP1 (physical association, affinity chromatography technology) Bennett et al., J Biol Chem 1999*
• IRef Biogrid Interaction: YY1 — SP1 (physical association, affinity chromatography technology) Li et al., J Cell Biochem 2008*
• IRef Biogrid Interaction: YY1 — SP1 (physical association, affinity chromatography technology) Santiago et al., Circ Res 2007*
• IRef Hprd Interaction: YY1 — SP1 (in vivo) Cole et al., Nucleic Acids Res 1997*
• IRef Hprd Interaction: YY1 — SP1 (in vitro) Cole et al., Nucleic Acids Res 1997*
• IRef Ophid Interaction: YY1 — SP1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Bennett et al., J Biol Chem 1999 : Thus, the specific interaction that occurs between SREBPs and Sp1 to stimulate the LDL receptor promoter is a specific target for inhibition by the YY1 protein, and we provide evidence that the mechanism can be at least partially explained by the ability of YY1 to inhibit the interaction between SREBP and Sp1 in solution in vitro
Dong et al., J Gen Virol 1999 : It is concluded that competition between SP1 and YY1 for DNA binding plays a major role in YY1 repression mediated by the binding site at positions 7840-7848
Erkeland et al., Blood 2003 (Cell Transformation, Neoplastic...) : Luciferase reporter assays showed that virus integration in this region increases promoter activity and renders it independent of a functional binding site for Sp1 , a major transcriptional regulator of YY1
Galvin et al., Mol Cell Biol 1997 : In contrast, physical interaction is not necessary for YY1 to repress Sp1- and CREB mediated transcription