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IFNG — TP63
Text-mined interactions from Literome
Cowdery et al., J Immunol 1999
:
Even though
IFN-gamma augmented LPS-driven
p40 promoter activity in RAW 264 cells, the combination of IFN-gamma and LPS induced less p40 mRNA or protein secretion than the combination of IFN-gamma and CpG DNA
Weinmann et al., Immunity 1999
:
In primary macrophages,
IFNgamma synergistically
enhanced p40 expression, but little effect on remodeling or promoter occupancy was observed
Campbell et al., Eur J Immunol 2000
:
Gal-lectin plus
IFN-gamma stimulated IL-12
p40 and p35 gene transcription with stable mRNA transcripts and a differential requirement for protein synthesis
NĂ©meth et al., Biochim Biophys Acta 2001
:
The effect of amiloride was post-transcriptional, as IL-12
p40 mRNA levels
induced by lipopolysaccharide and
interferon-gamma were not affected by this inhibitor
Costa et al., J Immunol 2001
(Encephalomyelitis, Autoimmune, Experimental) :
In vitro analysis demonstrated that IL-12
p40 suppressed
IFN-gamma production in developing and effector Th1 populations, indicating its potential to modulate Th1 promoted inflammation
Bastos et al., J Interferon Cytokine Res 2002
(Malaria...) :
Taken together, our results support the idea that the absence of
IL-12p40 not only
affects IFN-gamma production but also has deep consequences in macrophage effector functions that may contribute to exacerbation of the early phase of P. c. chabaudi malaria
Zhu et al., J Biol Chem 2003
:
In this study, a composite NFAT/ICSBP binding site at -68 to -54 is identified that is functionally important for
p40 promoter
activation by lipopolysaccharide (LPS) and LPS plus
IFN-gamma
Pedra et al., FEMS Immunol Med Microbiol 2007
(Anaplasmosis...) :
The lack of
IL-12/23p40 reduced
IFN-gamma production in both CD4 ( + ) and CD8 ( + ) T cells although the effect was more pronounced in CD4 ( + ) T cells
Yamauchi et al., International journal of biological sciences 2009
:
AZM reduced the
induction of
IL-12p40 by
LPS/IFN-gamma in a dose dependent manner
Ma et al., J Exp Med 1996
:
Because the RAW264.7 cell line is easily transfectable and regulates the endogenous IL-12
p40 gene in
response to
IFN-gamma or LPS similarly to human monocytes, it was used for analysis of the regulation of the cloned human IL-12 p40 promoter
Snijders et al., J Immunol 1996
:
We found that in LPS stimulated whole blood and purified monocytes, p70 and
p40 production are
enhanced by
IFN-gamma and inhibited by IL-10 and IL-4
Ertel et al., Blood 1997
(Endotoxemia) :
IFN-gamma dose-dependently ( P < .05 )
increased the release of IL-12
p40 and p70 into LPS stimulated whole blood from healthy humans without effect in whole blood from critically ill patients