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IL10 — IL23A
Text-mined interactions from Literome
Schuetze et al., Int Immunol 2005
:
Whereas p19 was induced early and transiently, p40 and p35 were up-regulated later and then continuously, but the secretion of
IL-23 and IL-12p70 was significantly
reduced by
IL-10
Happel et al., Alcohol Clin Exp Res 2006
(Klebsiella Infections) :
The
role of
IL-10 in alcohol mediated suppression of AM
IL-23 p19 mRNA expression was assessed using wild-type ( WT ) and IL-10 knock-out ( KO ) mice
Kim et al., FEMS Immunol Med Microbiol 2007
:
Taken together, these data suggest that LTA isolated from L. plantarum elicits stimulatory effects upon the expression of
IL-23p19 and inhibitory
effects on pathogen mediated
IL-10 production
Ong'echa et al., Clin Immunol 2008
(Anemia...) :
Since
IL-23 and IL-12 share the IL-12p40 subunit and IL-12Rbeta1 receptor, and are
down-regulated by
IL-10 , relationships among these cytokines were explored in Kenyan children with varying severities of malarial anemia
Albright et al., Immunol Lett 2009
(Colitis) :
Recombinant
IL-10 suppressed and anti-IL-10 receptor antibody
increased IFN-gamma, IL-17 and
IL-12/IL-23 p40 production in bacterial lysate pulsed APC and plus CD4 ( + ) T cell co-cultures
Correa et al., Glia 2010
(MAP Kinase Signaling System) :
Moreover, endogenously produced
IL-10 negatively
regulates IL-12 and
IL-23 cytokines, which in its turn modify the pattern of expression of transcription factors involved in Th commitment of splenocytes
Li et al., Immunol Cell Biol 2010
(Hepatitis B, Chronic) :
Furthermore, endogenous
IL-10 inhibited HBcAg stimulated production of IL-17A, IL-22, IL-6 and
IL-23 , but not TGF-ß
Zhang et al., Clin Neurol Neurosurg 2010
(Autoimmune Diseases...) :
IFNbeta inhibited IL-1beta,
IL-23 and transforming growth factor ( TGF ) -beta ( which induce Th17 cell differentiation ), and
induced IL-27, IL-12p35 and
IL-10 ( which suppress it ) in dendritic cells (DCs) and B-cells
Ahern et al., Immunity 2010
(Colitis) :
Furthermore,
IL-23R signaling in intestinal T cells
suppressed the differentiation of Foxp3 ( + ) cells and T cell
IL-10 production
Liu et al., Gastroenterology 2011
(Colitis) :
Blocking
IL-10 receptors
increased production of IFN-? and
IL-12/23p40 whereas exogenous IL-10 suppressed these cytokines
Liu et al., J Biol Chem 2012
(Inflammatory Bowel Diseases) :
This study aims to elucidate the
role of
IL-23 in the suppression of
IL-10 in the IBD intestinal mucosa
Tian et al., Invest Ophthalmol Vis Sci 2012
(Behcet Syndrome) :
VitD3 was able to
inhibit the gene expression of RORC, IL-17,
IL-23R , CCR6, and Th1 cell differentiation, but upregulated
IL-10 expression