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GP6 — SYK
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
SYK
→
GP6
(indirect_complex)
Sada et al., J Biochem 2001, Taniguchi et al., J Biol Chem 1991, Arias-Palomo et al., Biochim Biophys Acta 2009
-
Reactome Reaction:
SYK
→
GP6
(reaction)
Sada et al., J Biochem 2001, Taniguchi et al., J Biol Chem 1991, Arias-Palomo et al., Biochim Biophys Acta 2009, Peters et al., J Biol Chem 1996*
Text-mined interactions from Literome
Suzuki-Inoue et al., Biochem J 2004
:
Glycoproteins
GPVI and GPIb-IX-V
stimulate robust tyrosine phosphorylation of
Syk and PLCg2 ( phospholipase Cg2 ) in washed platelets, but only the former stimulates pronounced activation of phospholipase ... Using phospho-specific antibodies, we demonstrate that
GPVI , but not GPIb-IX-V,
stimulates significant tyrosine phosphorylation of
Syk at the autophosphorylation site pY525/526, a marker of Syk activity
Ohta et al., Biochem Biophys Res Commun 1992
:
These data suggest that
p72syk is a candidate of responsible protein-tyrosine kinase for platelet activation and that cell surface
glycoprotein is
involved in the activation of p72syk in platelets
Spalton et al., Journal of thrombosis and haemostasis : JTH 2009
:
The inhibitory effect of R406 provides direct evidence of a
role for
Syk in
GPVI , CLEC-2 and integrin alphaIIbbeta3 signaling in human platelets
Ichinohe et al., J Biol Chem 1995
(Thrombasthenia) :
Cyclic AMP-insensitive
activation of c-Src and
Syk protein-tyrosine kinases through platelet membrane
glycoprotein VI
Ezumi et al., J Exp Med 1998
:
We have previously shown that uncharacterized
glycoprotein VI (GPVI) , which is constitutively associated and coexpressed with Fc receptor gamma chain (FcRgamma) in human platelets, is
essential for collagen stimulated tyrosine phosphorylation of FcRgamma,
Syk , and phospholipase Cgamma2 ( PLCgamma2 ), leading to platelet activation
Barnes et al., Curr Opin Hematol 1998
:
Platelet activation then follows from the recognition by the receptor Gp VI of GPP* sequences in collagen, culminating in signalling events unique to collagen as a platelet agonist :
Gp VI leads via the novel platelet Fc receptor gamma-chain to
p72syk and phospholipase Cgamma2