van Leeuwen et al., Adv Cancer Res 2009
(Neoplasms) :
Preliminary observations also suggest that sirtuin mediated modulation of p53 can also take place indirectly through changes in cellular processes ( e.g., nucleolar function and p300 activity ) known to affect p53
Lynch et al., PloS one 2010
:
Thus, SIRT1 mediated inhibition of p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing
van Leeuwen et al., Mol Cancer Ther 2013
:
These results help understand why inhibition of both SirT1 and SirT2 is needed to achieve effective activation of p53 by small-molecule sirtuin inhibitors