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CCL2 — SYK

Text-mined interactions from Literome

Arndt et al., J Biol Chem 2004 : Inhibition of Syk with piceatannol or PI3K with wortmannin inhibited LPS induced JNK activation and decreased MCP-1 expression after exposure to LPS, suggesting that both Syk and PI3K reside in a signaling pathway leading to LPS induced JNK activation in neutrophils
Olsnes et al., BMC immunology 2009 (Carcinoma, Squamous Cell...) : Inhibition of Syk kinase and/or PI-3 kinase did not significantly change the chemokine response to OK-432, except for MIP-1alpha production being increased upon Syk inhibitor addition and an increased MCP-1 response upon addition of both inhibitors
Koo et al., Cell Biol Int 2013 : We have investigated whether MPA regulates Syk to repress tumour necrosis factor-a (TNF-a) induced MCP-1 production in cultured human aortic endothelial cells ... TNF-a induced MCP-1 mRNA expression was inhibited by N-acetylcysteine (NAC), Syk inhibitor, Syk-siRNA and MPA ... TNF-a induced MCP-1 protein production was also inhibited by Syk inhibitor and MPA