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HES4 — TNF
Text-mined interactions from Literome
Kawaguchi et al., Biol Pharm Bull 2004
(Salmonella Infections, Animal...) :
In addition,
HES markedly
suppressed plasma levels of
TNF-alpha and high mobility group box chromosomal protein 1 ( HMGB-1 ), decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection
Lv et al., Acta Anaesthesiol Scand 2005
:
HES significantly
reduced the increased hepatic levels of
TNF-alpha , IL-1beta, IL-6, IL-8 and the mRNAs in the endotoxemic rats
Lv et al., J Int Med Res 2005
(Endotoxemia...) :
HES significantly
reduced the LPS induced increase in intestinal levels of
TNF-alpha , IL-1beta, IL-6, IL-8 and their corresponding mRNAs
Lv et al., Anesth Analg 2006
(Endotoxemia) :
HES significantly
reduced the increased intestinal levels of
tumor necrosis factor-alpha , IL-6, cytokine induced neutrophil chemoattractant-1, and the mRNAs in the endotoxemic rats
Wang et al., Int Immunopharmacol 2009
(Disease Models, Animal...) :
In addition, both
HES and BL could
attenuate the increase in
TNF-alpha , IL-6, MPO levels and NF-kappaB activation
Feng et al., Int Immunopharmacol 2010
(Disease Models, Animal...) :
Meanwhile,
HES could significantly
reduce TNF-alpha , IL-6, and ICAM-1 mRNA, inhibit NF-kappaB activation, and down-regulate TLR2 and TLR4 expression in the brain
Sun et al., Chin Med J (Engl) 2011
(Reperfusion Injury) :
HES130/0.4 lessened the release of
TNF-a and IL-1ß consistent with the reduction of MPO activity, and
HES 130/0.4
inhibited the activity of NF-?B in H-I/R group
Schick et al., BMC gastroenterology 2012
(Blood Coagulation Disorders...) :
HES improved liver microcirculation, cardiac index and DO2-I, but significantly
increased IL-1ß, IL-6 and
TNF-a levels and resulted in a mortality rate of 33 %