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MECP2 — UBE3A

Text-mined interactions from Literome

Samaco et al., Hum Mol Genet 2005 (Angelman Syndrome...) : Here, we test the hypothesis that MECP2 deficiency may affect the level of expression of UBE3A and neighboring autism candidate gene GABRB3 without necessarily affecting imprinted expression ... These results suggest an overlapping pathway of gene dysregulation within 15q11-q13 in Rett, Angelman and autism and implicate MeCP2 in the regulation of UBE3A and GABRB3 expressions in the postnatal mammalian brain
Jordan et al., Hum Mol Genet 2006 (Disease Models, Animal...) : Here, we tested the hypothesis that MeCP2 deficiency affects expression of Ube3a in mouse models of RTT
Lawson-Yuen et al., Brain Res 2007 (Disease Models, Animal...) : As MeCP2 regulates gene expression, this has led to the hypothesis that MeCP2 may regulate UBE3A expression ; however, there are conflicting reports regarding the expression of Ube3a in MeCP2 null mutant mice