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FUT1 — NFKB1
Text-mined interactions from Literome
Uwagawa et al., Cancer 2007
(Adenocarcinoma...) :
In an attempt to identify an effective therapeutic agent for pancreatic cancer, the authors studied the
role of
FUT-175 , a synthetic serine protease inhibitor, in the inhibition of
NF-kappaB activation and the induction of apoptotic responses ... To examine the
effect of
FUT-175 on the inhibition of
NF-kappaB and the induction of apoptosis in pancreatic cancer cell lines, Western and Northern blot analyses, electromobility shift ( EMSA ), luciferase reporter gene, DNA fragmentation, immunoprecipitation, in vitro kinase, small interfering RNA ( siRNA ), and chromatin immunoprecipitation ( ChIP ) assays were performed ... In a time dependent and dose dependent manner,
FUT-175 inhibited IkappaBalpha phosphorylation and
NF-kappaB activation, thereby inhibiting the antiapoptotic activity of NF-kappaB
Lim et al., Int J Biochem Cell Biol 2008
:
Since
NF-kappaB p65 activation
induced the decrease of
Hsc70 level, the interaction of Ku70 with importin-alpha and nuclear translocation of Ku70 increased upon the activation of NF-kappaB p65 ... In the cells treated with cerulein as a physiological stimulus to activate NF-kappaB p65, nuclear translocation of Ku70 increased through
NF-kappaB p65
mediated decrease of
Hsc70 level
Zou et al., Am J Physiol Heart Circ Physiol 2008
(Disease Models, Animal...) :
Recombinant
HSC70 induced
NF-kappaB activation and cytokine expression and depressed myocardial contractility in a TLR4 dependent manner