Gene interactions and pathways from curated databases and text-mining

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IFNB1 — NFKB1

Pathways - manually collected, often from reviews:

  • WikiPathways EBV LMP1 signaling: NFKB1/RELA → Complex of CXCL8-IFNB1-CCL20-TNF-CCL5 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Algarté et al., J Virol 1999 (Respirovirus Infections) : These experiments demonstrate a major role for IkappaBalpha in the regulation of NF-kappaB induced IFN-beta gene activation and a minor role for IkappaBbeta in the activation process
Fang et al., J Neurovirol 2001 : Induction of IFN-beta and MHC class I gene expression requires NF-kappaB activation which depends on degradation of IkappaBalpha, an inhibitory protein of NF-kappaB
Escalante et al., Structure 2002 : Upon viral infection, NF-kappaB translocates to the nucleus and activates the IFN-beta gene by binding to the PRDII element
Kim et al., J Neurochem 2002 : IFNbeta induced IkappaBalpha degradation and NF-kappaB ( p65 : p50 ) DNA binding
Rani et al., J Biol Chem 2002 (Fibrosarcoma) : IFN-beta treatment did not augment the abundance of NF-kappa B , but led to phosphorylation of the NF-kappa B subunit p65 and induced a nuclear activity capable of phosphorylating a p65-GST fusion construct in the carboxy-terminal transactivation domain ( TAD ), residues 354-551
Yamamoto et al., J Immunol 2002 : Dominant negative TRIF inhibited TLR3 dependent activation of both the NF-kappaB dependent and IFN-beta promoters
Thanos et al., Cell 1992 (Tumor Virus Infections) : In this paper, we show that both NF-kappa B and the high mobility group protein I ( Y ) ( HMG I(Y) ) are required for virus induction of the human interferon-beta (IFN-beta) gene
Bose et al., J Interferon Cytokine Res 2003 (Paramyxoviridae Infections) : The antiviral cytokine IFN-alpha/beta ( IFN type I ) produced following viral infection as a result of activation of NF-kappaB or IRF-3 or both exerts an antiviral state by inducing the Janus kinases/signal transducer and activator ( Jak-Stat ) pathway
van Holten et al., Arthritis Res Ther 2004 (Arthritis, Experimental...) : We also examined the effect of IFN-beta on NF-kappaB activity
Harii et al., Mol Endocrinol 2005 (Thyroiditis, Autoimmune...) : In this report, we demonstrate TLR3 mRNA and protein are expressed on Fisher rat thyroid cell line-5 ( FRTL-5 ) thyroid cells and are functional because incubating cells with polyinosine-polycytidylic acid causes 1 ) transcriptional activation of both the nuclear factor kappaB (NF-kappaB)/Elk1 and interferon (IFN) regulatory factor-3/IFN-beta signal paths, 2 ) posttranscriptional activation of NF-kappaB and ERK1/2, and 3 ) increased IFN-beta mRNA
Aksoy et al., Eur J Immunol 2005 : Experiments carried out in HEK 293T cells stably expressing TLR3 or TLR4 confirmed that inhibition of PI3K activity enhances NF-kappaB dependent promoters as well as IFN-beta promoter activities without interfering with transcription at the positive regulatory domain III-I
O'Donnell et al., J Clin Invest 2005 (Myocarditis...) : Treatment of p50-null mice with IFN-beta substantially diminished reovirus replication and apoptosis, which suggests that IFN-beta induction by NF-kappaB protects against reovirus induced myocarditis
Seth et al., Cell 2005 (Respirovirus Infections) : Conversely, overexpression of MAVS induces the expression of IFN-beta through activation of NF-kappaB and IRF 3, thus boosting antiviral immunity
Chang et al., Microbes Infect 2006 : NF-kappaB activation is essential for IFN-beta induction in JEV- and DEN-2 infected cells
Iversen et al., J Immunol 2005 : Activated NK cells expressed lymphotoxin ( LT ) alphabeta on their cell surface, and secreted LTalpha and TNF, all of which contributed to the NF-kappaB dependent release of IFN-beta from infected fibroblasts
Liu et al., J Virol 2007 : In contrast, siRNA mediated TLR3 knockdown did not affect RSV induced NF-kappaB binding but did inhibit IFN-beta , IP-10, CCL-5, and ISG15 expression at late times of infection
Ock et al., J Neurosci Res 2007 (Inflammation) : Hypoxia, however, differentially regulated MyD88 dependent and -independent pathways of TLR4 signaling : Hypoxia enhanced lipopolysaccharide (LPS) induced interferon regulatory factor-3 (IRF-3) activation and the subsequent expression of IFNbeta ( MyD88 independent pathway ), whereas it suppressed LPS induced NF-kappaB activation ( MyD88 dependent pathway )
Suh et al., J Virol 2007 (Cytomegalovirus Infections...) : PIC induction of IDO was mediated in part by IFN-beta but not IFN-gamma, and both NF-kappaB and interferon regulatory factor 3 (IRF3) were required
Lefort et al., J Virol 2007 : Of interest, ifn-beta gene activation by K-bZIP is independent of interferon ( IFN ) -responsive factor 3 ( IRF-3 ) and nuclear factor kappaB (NF-kappaB) activation
Rui et al., J Immunol 2007 : In this study, we demonstrate that PECAM-1 ligation with CD38-Fc fusion protein negatively regulates LPS induced proinflammatory cytokine TNF-alpha, IL-6, and IFN-beta production by inhibiting JNK, NF-kappaB , and IFN regulatory factor 3 activation in macrophages
Kotla et al., Virology 2008 : The type I interferon ( IFN ) response requires the coordinated activation of the latent transcription factors NF-kappaB , IRF-3 and ATF-2 which in turn activate transcription from the IFN-beta promoter
Alff et al., J Virol 2008 : The formation of TBK1-TRAF3 complexes directs IRF-3 phosphorylation, and both IRF-3 and NF-kappaB activation are required for transcription from the IFN-beta promoter
Kaiser et al., J Immunol 2008 : Suppression of RIP1 expression by RNAi abrogates NF-kappaB activation as well as IFNbeta induction by immunostimulatory DNA
Li et al., Biochem Biophys Res Commun 2009 (Herpes Genitalis) : More importantly, our data provide direct evidence that the activation of NF-kappaB is required for the production of both IL-6 and IFN-beta induced by HSV-2 in HCE cells
Wu et al., Hepatology 2009 : Pretreatment of hepatocytes and NPCs with HBV-Met cells supernatants, HBsAg, HBeAg, or HBV virions almost completely abrogated TLR induced antiviral activity, which correlated with suppression of interferon beta (IFN-beta) production and subsequent interferon stimulated gene induction as well as suppressed activation of interferon regulatory factor 3 (IRF-3), nuclear factor kappa B (NF-kappaB) , and extracellular signal regulated kinase ( ERK ) 1/2
Myskiw et al., J Virol 2009 : IL-6 induction is regulated by NF-kappaB, while IFN-beta induction is mediated by IFN-beta promoter stimulator 1 and IFN regulatory factor 3/NF-kappaB
Daffis et al., PLoS Pathog 2009 (West Nile Fever) : However, pharmacological inhibition of NF-kappaB and ATF-2/c-Jun, the two other known components of the IFN-beta enhanceosome, strongly reduced IFN-beta gene transcription in the DKO dendritic cells
Mao et al., J Biol Chem 2010 : Here we show that knockdown of the E3 ubiquitin ligases cIAP1 and cIAP2 markedly inhibited virus triggered activation of IRF3 and NF-kappaB as well as IFN-beta induction
Li et al., J Virol 2010 : However, knockdown of RIG-I only partially blocked NF-kappaB activity induced by MHV infection and inhibition of NF-kappaB activity by a decoy peptide inhibitor had little effect on IFN-alpha/beta production
Zheng et al., J Immunol 2010 : In addition to promoting both MyD88- and TLR/IL-1 receptor domain containing adaptor protein inducing IFN-beta dependent MAPKs and NF-kappaB activation, Gab1 enhances PI3K/Akt activation by directly binding p85 in TLR signaling and VSV infection
Dhib-Jalbut et al., J Immunol 1995 : Induction of IFN-beta gene expression by virus requires binding of NF-kappa B to the positive regulatory domain II element of the IFN-beta promoter