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ARPC4 — RAC1

Pathways - manually collected, often from reviews:

• Reactome Reaction: ARPC4 → RAC1 (reaction) Takenawa et al., J Cell Sci 2001, Zalevsky et al., Curr Biol 2001, Le Clainche et al., Proc Natl Acad Sci U S A 2003, Kovar et al., Nat Cell Biol 2006
• Reactome Reaction: ARPC4 → RAC1 (indirect_complex) Takenawa et al., J Cell Sci 2001, Zalevsky et al., Curr Biol 2001

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 177 proteins (association, cross-linking study) Byron et al., Proteomics 2012
• IRef Intact Interaction: Complex of 400 proteins (association, cross-linking study) Humphries et al., Science signaling 2009
• IRef Intact Interaction: Complex of 203 proteins (association, cross-linking study) Byron et al., Proteomics 2012

Text-mined interactions from Literome

Fucini et al., Mol Biol Cell 2002 : Actin recruitment involves Cdc42/Rac and requires the activation of the Arp2/3 complex
Olazabal et al., Curr Biol 2002 : Rac and Cdc42 are required for actin and Arp2/3 complex recruitment during FcgammaR phagocytosis, while Rho controls actin assembly at CR phagosomes
Smith et al., Curr Biol 2004 : WAVE/SCAR has long been known to activate the actin nucleating Arp2/3 complex in a Rac dependent manner
Shi et al., J Biol Chem 2005 : The dramatic reorganization of the actin cytoskeleton required for internalization is driven by bacterial manipulation of host signaling pathways, including activation of the Rho family GTPase Rac1 and subsequent activation of the Arp2/3 complex
Hall et al., Immunity 2006 : In addition, a Rac1/2 or Vav1/3 deficiency blocks Arp2/3 recruitment and actin polymerization at the complement induced phagosome, indicating that these proteins regulate early steps in phagocytosis
Ten Klooster et al., Biochem J 2006 : Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization