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RAC1 — SLC2A4

Text-mined interactions from Literome

Khayat et al., J Cell Sci 2000 : Transient transfection of dominant inhibitory Rac1 ( N17 ) into L6 myotubes prevented formation of dorsal actin structures and blocked insulin induced GLUT4myc translocation to the cell surface
Randhawa et al., J Biol Chem 2008 : GLUT4 vesicle recruitment and fusion are differentially regulated by Rac , AS160, and Rab8A in muscle cells
Ueda et al., FASEB J 2010 : We show that ectopic expression of constitutively activated Rac1 , as well as intravenous administration of insulin, caused translocation of GLUT4 to the gastrocnemius muscle sarcolemma, as revealed by immunofluorescent staining of a transiently expressed exofacial epitope tagged GLUT4 reporter ... Collectively, we propose a critical role of Rac1 in insulin dependent GLUT4 translocation to the skeletal muscle sarcolemma, which has heretofore been predicted solely by cell culture studies
Nozaki et al., Cell Signal 2012 : The purpose of this study is to examine the involvement of RalA in Rac1 regulation of the translocation of GLUT4 to the plasma membrane in muscle cells ... GLUT4 translocation induced by constitutively activated mutation of Rac1 or more physiologically by upstream Rac1 regulators, such as phosphoinositide 3 kinase and the guanine nucleotide exchange factor FLJ00068, was abrogated when the expression of RalA was downregulated by RNA interference ... Collectively, we propose a novel mechanism involving RalA for Rac1 mediated GLUT4 translocation in skeletal muscle cells
Chiu et al., J Biol Chem 2013 (Insulin Resistance) : Interestingly, constitutively active Rac-1 expression results in a hormone independent increase in surface GLUT4 ; however, the molecular mechanism and significance behind this effect remain unresolved