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NA — NOX3
Text-mined interactions from Literome
Rao et al., J Biol Chem 1999
:
To understand the role of redox-sensitive mechanisms in vascular smooth muscle cell ( VSMC ) growth, we have studied the effect of
N-acetylcysteine (NAC) , a thiol antioxidant, and diphenyleneiodonium ( DPI ), a potent
NADH/NADPH oxidase inhibitor , on serum-, platelet derived growth factor BB-, and thrombin induced ERK2, JNK1, and p38 mitogen activated protein ( MAP ) kinase activation ; c-Fos, c-Jun, and JunB expression ; and DNA synthesis
Guo et al., Am J Physiol Heart Circ Physiol 2007
(Diabetes Mellitus, Experimental) :
We investigated the
effect of
N-acetyl-l-cysteine (NAC) on the expression of nicotinamide adenine dinucleotide phosphate (
NADPH ) oxidase , antioxidant enzymes, and inflammatory markers in diabetic rat hearts
Lin et al., Br J Pharmacol 2010
:
Additionally,
NAC blocked NFAT3 activation by inhibition of
NADPH oxidase activation, and ERK/JNK and PKC pathways, resulting in a decrease in cell apoptosis ; the therapeutic effect of NAC was verified in vivo
Marino et al., Cell death & disease 2010
(Melanoma) :
The ROS scavenger
N-acetyl-L-cysteine (NAC) and
inhibition of
NADPH oxidase significantly reduced ESOM induced cell death, consistent with inhibition of cytosolic acidification
Lei et al., Yonsei Med J 2012
(Diabetes Mellitus, Experimental) :
The current study shows that
NAC inhibits
NADPH oxidase activation in diabetes and attenuates tissue oxidative damage in all organs, even though its effects on antioxidant activity are tissue specific