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MMP2 — RECK
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Liu et al., Oncogene 2002
(Lung Neoplasms) :
Recent works demonstrated that a membrane anchored MMP inhibitor
RECK may potently
suppress MMP-2 and -9 activity to inhibit angiogenesis and metastasis in vitro and in vivo ... In this study, we test the possibility that NSAIDs may up-regulate
RECK to
inhibit MMP activity
Masui et al., Clin Cancer Res 2003
(Adenocarcinoma...) :
When artificially expressed in such cell lines,
RECK negatively
regulates at least matrix metalloprotease (MMP)-9,
MMP-2 , and MT1-MMP activation and suppresses the invasive and metastatic potentials of these cells
Liu et al., Cancer Res 2003
(Lung Neoplasms...) :
Histone deacetylase inhibitor up-regulates
RECK to
inhibit MMP-2 activation and cancer cell invasion ... In this study, we test the possibility that HDAC inhibitor may increase
RECK expression to
inhibit MMP activation and cancer cell invasion ... Moreover, up-regulation of
RECK expression by TSA
attenuated MMP-2 activity
Oh et al., Cancer Res 2004
(Melanoma) :
TIMP-2 and Ala+TIMP-2 also suppress basal hMVEC migration via a time dependent mechanism mediated by enhanced expression of
RECK , a membrane anchored
MMP inhibitor , which, in turn, inhibits cell migration
Simizu et al., Cancer Res 2005
(Neoplasm Invasiveness) :
RECK , a glycosylphosphatidylinositol (GPI) anchored glycoprotein, negatively
regulates matrix metalloproteinases ( MMP ) , such as MMP-9, and inhibits tumor invasion and metastasis
Oh et al., Oncogene 2006
:
We previously demonstrated that TIMP-2 increases the association of Crk with C3G and via subsequent activation of Rap1 enhances the expression of
RECK , a membrane anchored
MMP inhibitor
Paulissen et al., Mol Med 2006
(Asthma...) :
mRNA expression profile of selected ADAM and ADAMTS proteinases ( ADAM-8, -9, -10, -12, -15, -17, and -33 ; ADAMTS-1, -2, -15, -16, -17, -18, and -19 ), their physiological inhibitors TIMP-1 and TIMP-3, and
RECK , a membrane anchored
MMP activity
regulator , was obtained by RT-PCR analysis performed on cells collected by sputum induction from 21 patients with mild to moderate asthma and 17 healthy individuals
Kang et al., J Orthop Res 2007
(Bone Neoplasms...) :
The level of RECK expression was inversely correlated with pro-MMP-2 activation, and overexpression of
RECK by transfection
resulted in decreased
pro-MMP-2 activation and reduced tumor invasiveness
Lee et al., J Cell Biochem 2008
:
Here, we examined the expression of
RECK , a novel membrane anchored
MMP inhibitor , in PSCs
Takagi et al., Cancer Res 2009
(Fibrosarcoma) :
RECK , a glycosylphosphatidylinositol anchored glycoprotein,
inhibits the enzymatic activities of some
matrix metalloproteinases ( MMP ) , thereby suppressing tumor cell metastasis ; however, the detailed mechanism is still obscure
Walsh et al., Journal of cell communication and signaling 2012
:
TIMP-2, the most studied member of the family, can both inhibit and activate MMPs directly, as well as
inhibit MMP activity indirectly by upregulating expression of
RECK , a membrane anchored MMP regulator
Zhang et al., Endocrine 2012
:
These studies demonstrate that RECK expression in the mouse uterus is steroidally regulated and that within endometrial epithelial and stromal cells,
RECK regulates MMP9, but not
MMP2 activity