◀ Back to PRKAR2B
PGP — PRKAR2B
Text-mined interactions from Literome
Parissenti et al., Int J Cancer 1999
(Breast Neoplasms) :
In contrast with findings in Chinese hamster ovary and Y1 adrenal cells, P-gp levels and cellular sensitivity to drugs which are P-gp substrates were unchanged in the PKA inhibited transformants, suggesting that
P-gp expression and function are not under
PKA dependent control in MCF-7 ( ADR ) cells
Wartenberg et al., Int J Cancer 2000
(Prostatic Neoplasms) :
Down-regulation of Pgp by H ( 2 ) O ( 2 ) was abolished when either forskolin, 8-Br-cAMP or IBMX, which raise intracellular cAMP levels, was co-administered, indicating that
Pgp expression is
regulated by
protein kinase A (PKA) ... Furthermore,
Pgp was
down-regulated by the
PKA inhibitors Rp-cAMPs and H89