◀ Back to IL1B

COL2A1 — IL1B

Text-mined interactions from Literome

Robbins et al., Arthritis Rheum 2000 : The p38 MAPK-selective inhibitor, SB203580, partially reversed IL-1beta induced inhibition of COL2A1 mRNA levels and COL2A1-luciferase reporter gene expression ... These studies also show, for the first time, that p38 MAPK is one of the signals required for IL-1beta induced inhibition of COL2A1 gene expression
Chadjichristos et al., J Biol Chem 2003 : Specificity of IL-1 beta effects on COL2A1 promoter activity was demonstrated in experiments in which transfection of a wild type -50/+1 sequence of COL2A1 promoter as a decoy oligonucleotide abolished the IL-1 beta inhibition of a -63/+47 COL2A1 mediated transcription
Sandell et al., Osteoarthritis Cartilage 2008 (Arthritis) : In the presence of IL-1beta , FGF-18 increased expression of ADAMTS-4, aggrecan, BMP-2, COL2A1 , CCL3, CCL4, CCL20, CXCL1, CXCL3, CXCL6, IL-1beta, IL-6, and IL-8 and decreased ADAMTS-5, MMP-13, CCL2, and CCL8
Cailotto et al., J Biol Chem 2010 : Transient overexpression of Ank counteracted most of IL-1beta effects on Type II collagen , Sox-9, and Wnt-5a expression