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IL1B — SPAG8

Text-mined interactions from Literome

Friedberg et al., J Clin Endocrinol Metab 2003 : IL-1 beta also up-regulated 11 beta-HSD-1 activity maximally at 0.6 x 10 ( -9 ) M ( 160 +/- 33 % ; P < 0.001 ) and caused an increase in glycerol levels ( 159 +/- 11 % of control ; P < 0.001 )
Johnstone et al., J Soc Gynecol Investig 2005 (Chorioamnionitis...) : In JEG-3 cells, 11beta HSD-1 32-kd expression was increased with interleukin (IL)-1beta and tumor necrosis factor alpha (TNF-alpha), while 11beta HSD-2 expression was unaffected
Li et al., Endocrinology 2006 : Using real-time PCR and enzyme activity assay, we found that cortisol ( 1 mum ) and IL-1beta ( 10 ng/ml ) for 24 h significantly increased 11beta-HSD1 mRNA expression and reductase activity in cultured human chorionic trophoblasts ... We conclude that cortisol up-regulates 11beta-HSD1 expression through induction of promoter activity, and the effect was enhanced by IL-1beta , suggesting that more biologically active glucocorticoids could be generated in the fetal membranes in the presence of infection, which may consequently feed forward in up-regulation of prostaglandin synthesis
Yang et al., J Clin Endocrinol Metab 2009 : We examined the expression of 11beta-HSD1 and its regulation by cortisol and IL-1beta in human fetal lung ... The induction of 11beta-HSD1 by IL-1beta was further increased by cortisol, whereas the induction of cyclooxygenase 2 by IL-1beta was inhibited by cortisol ... Nuclear factor kappaB activation inhibitor could only block the induction of cyclooxygenase 2 but not 11beta-HSD1 by IL-1beta , suggesting that different mechanisms were utilized by IL-1beta in the regulation of 11beta-HSD1 versus proinflammatory mediators ... Global inhibition of CCAAT-enhancer binding proteins ( C/EBPs ) with transfection of C/EBP-specific dominant negative expression plasmid could attenuate the induction of 11beta-HSD1 by IL-1beta , suggesting that C/EBPs may mediate the induction of 11beta-HSD1 by IL-1beta