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BSG — MMP2
Text-mined interactions from Literome
Sameshima et al., Cancer Lett 2000
(Brain Neoplasms...) :
Thus, we have shown, for the first time, that
EMMPRIN causes increased expression of MT1-MMP and
MT2-MMP , as well as increased production and activation of MMP-2 ... Thus, we have shown, for the first time, that
EMMPRIN causes increased expression of MT1-MMP and MT2-MMP, as well as increased production and activation of
MMP-2
Sun et al., Cancer Res 2001
(Fibrosarcoma...) :
Purified native
CD147 induced the production of secreted
MMP not only by dermal fibroblasts ( MMP-1 ) but also by MDA-435 cells themselves ( MMP-2 ), suggesting homophilic CD147 binding may occur in the context of both heterotypic and homotypic cell-cell interactions ... Our results suggest that homophilic
CD147 interactions may
play a key role in
MMP-2 production and tumor cell invasion, and that perturbation of this molecule may have potential therapeutic uses in the prevention of MMP-2 and MMP-1 dependent cancer metastasis
Caudroy et al., Clin Exp Metastasis 2002
(Breast Neoplasms...) :
EMMPRIN mediated
MMP regulation in tumor and endothelial cells
Thorns et al., Anticancer Res 2003
(Hodgkin Disease) :
The expression of
EMMPRIN in the tumour cells may
induce the expression of
MMP-2 in the surrounding non-neoplastic cells
Tang et al., J Biol Chem 2004
:
CD147 , a
regulator of
matrix metalloproteinase ( MMP ) production, showed highly specific association with caveolin-1 on the surface of multiple cell types
Tang et al., Mol Biol Cell 2004
:
It was shown previously that caveolin-1 associates with CD147, thus inhibiting
CD147 self-aggregation and
MMP induction ; now we show that caveolin-1 associates with LG-CD147 and restricts the biosynthetic conversion of LG-CD147 to HG-CD147 ... In addition, HG-CD147 ( but not LG-CD147 ) was preferentially captured as a multimer after treatment of cells with a homobifunctional cross linking agent and was exclusively recognized by monoclonal antibody AAA6, a reagent that selectively recognizes self associated
CD147 and
inhibits CD147 mediated
MMP induction
Haug et al., Arterioscler Thromb Vasc Biol 2004
:
MMP-1 and MMP-2 synthesis was upregulated by oxLDL, and, in addition, we have shown that soluble
EMMPRIN , isolated from macrophage supernatants,
increased MMP-1 and
MMP-2 synthesis in HCA-SMC ... Additionally, oxLDLs might induce a circular upregulation of matrix degradation because, in turn, soluble
EMMPRIN stimulates
MMP synthesis in HCA-SMC
Gabison et al., Am J Pathol 2005
(Corneal Ulcer) :
Here we demonstrate a
role for
EMMPRIN in
MMP induction during corneal wound healing
Smedts et al., Biol Reprod 2005
:
This report characterizes the expression pattern of
basigin (Bsg) , a putative
regulator of
MMP induction, in the rat ovary
Gabison et al., Biochimie 2005
(Disease Progression...) :
Later studies have shown that
EMMPRIN can also
induce MMP in the same population of cells ... The presence and modulation of EMMPRIN in normal tissues associated with increased MMP expression suggests that this
EMMPRIN mediated
MMP induction could be a common mechanism in non-tumoral physiological and/or pathological situations
Zhou et al., BMC cell biology 2005
:
Involvement of
CD147 in overexpression of
MMP-2 and MMP-9 and enhancement of invasive potential of PMA differentiated THP-1 ... The results suggest that the expression of CD147 is upregulated during the differentiation of monocyte THP-1 cells to macrophage cells, and
CD147 induces the secretion and activation of
MMP-2 and MMP-9 and enhances the invasive ability of THP-1 cells
Zhu et al., Arthritis Res Ther 2005
(Arthritis, Rheumatoid...) :
The
role of
CD147 in
MMP production and cell invasion in vitro were studied through the co-culture of human CD14+ monocytes or monocytic line THP-1 cells and human fibroblasts, as well as by gel zymography and an invasion assay ... Our study demonstrates that the increased expression of
CD147 on monocytes/macrophages in RA may be
responsible for elevated
MMP secretion, cell invasion and CyPA mediated cell migration into the joints, all of which may contribute to the cartilage and bone destruction of RA
Sluijter et al., Stroke 2006
(Carotid Artery Diseases...) :
Different EMMPRIN glycosylation forms are associated with either MMP-2 or MMP-9 activity, which suggests that
EMMPRIN glycosylation may
play a role in
MMP regulation and plaque destabilization
Zhu et al., Arthritis Res Ther 2006
(Arthritis, Rheumatoid...) :
The
role of
CD147 in
MMP production and the cells ' invasiveness in vitro were studied by the co-culture of FLS with the human THP-1 cell line or monocytes/macrophages, by gel zymography and by invasion assay ... Our studies demonstrated that the
CD147 overexpression on monocytes/macrophages and FLS in RA patients may be
responsible for the enhanced
MMP secretion and activation and for the invasiveness of synoviocytes
Barth et al., Histochem Cell Biol 2006
(Pulmonary Fibrosis) :
Experimental in vitro data has showed that
MMP inducing activity of
CD147 is under the control of caveolin-1
Egawa et al., J Biol Chem 2006
:
The N-terminal Ig-like domain is important for the
MMP inducing activity of
EMMPRIN and for cell-cell interactions, presumably through its ability to engage in homophilic interactions, and the 22-kDa fragment retained the ability to augment MMP-2 expression in human fibroblasts
Li et al., Cancer Sci 2007
(Breast Neoplasms...) :
Using quantitative real-time polymerase chain reaction and Western blot, we found that overexpression of
CD147 in MCF7 cells
up-regulated MDR1,
MMP2 , and MMP9 on both transcription and expression levels, which promoted tumor cells metastasis and conferred them multidrug resistance to P-gp substrate drugs, as determined by in vitro invasion assay and 3- ( 4,5-dimethylthiazol-2-yl ) -2,5-diphenyltetrazolium bromide ( MTT ) assay
Gallagher et al., Cancer Res 2007
(Breast Neoplasms) :
The synergistic activities of the MCT/CD147 complex could facilitate migration of tumor cells by
CD147 mediated
MMP induction and lactate stimulated angiogenesis and hyaluronan production
Liang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007
(Arthritis, Rheumatoid) :
To study the
effects of
CD147 on neutrophil on
matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) production by fibroblast-like synoviocytes ( FLS ) and the invasive potential of FLS in rheumatoid arthritis ( RA ) ... To further investigate the
effect of
CD147 on neutrophil on
MMP production by FLS and the invasive potential of FLS in RA, antagonist peptide against EMMPRIN/CD147 ( AP-9 ) was added to the coculture
Siwik et al., J Mol Cell Cardiol 2008
:
Therefore, we tested the hypothesis that
EMMPRIN expression
regulates matrix metalloproteinase ( MMP ) activity in rat ventricular myocytes in vitro ... To determine whether
EMMPRIN expression
regulates matrix metalloproteinase ( MMP ) activity, EMMPRIN activity was inhibited by adenoviral expression of an inhibitory mutant of EMMPRIN ... Expression of mutant
EMMPRIN inhibited the betaAR stimulated increases in MMP2 expression and zymographic
MMP activity ... The resulting increase in
EMMPRIN activity
stimulates MMP expression and activity
Burggraf et al., Thromb Haemost 2007
(Disease Models, Animal...) :
The inducer protein
EMMPRIN increased in parallel to its substrate
MMP-2
Huang et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008
(Neoplasm Invasiveness) :
The results showed that the expression of CD147 was elevated by the induction of LPS, and the enhanced expression of
CD147 on U937 cells
increased the production and secretion of
MMP-2 and MMP-9 as measured by reverse transcription-PCR and gel zymography ... It is concluded that overexpression of
CD147 on U937 cells may
increase the secretion and activation of
MMP-2 and MMP-9 and thus promote the invasiveness of the tumor cells
Hanata et al., Arch Histol Cytol 2007
(Laryngeal Neoplasms) :
Depending on the cell type,
EMMPRIN can
stimulate the production of MMP-1,
MMP-2 , and MMP-3
Ahlén et al., Sarcoma 2001
:
The covariation between EMMPRIN and MMP-2 support previous findings that
EMMPRIN may be an
inducer of
MMP-2
Dang et al., Anticancer Res 2008
(Carcinoma, Squamous Cell...) :
Thus
EMMPRIN regulates migration,
MMP production by SCC cells and deposition of the TN-C matrix
Gabison et al., Prog Retin Eye Res 2009
:
Our studies which aimed to explore mechanisms of matrix degradation in pathological corneal wound healing have shown that
EMMPRIN , a glycoprotein expressed on corneal epithelial cell surface, can
induce matrix metalloproteinase ( MMP ) production and myofibroblasts differentiation after direct interaction with corneal fibroblasts
Wu et al., Cell Biol Int 2009
(Carcinoma, Hepatocellular...) :
The overexpression of
HAb18G/CD147 increased MMPs ' (
MMP-2 and MMP-9 ) production ( P < 0.01 ), and was obviously accompanied with enhanced expressions of paxillin, FAK and p-FAK in 3-D cell co-culture model
Zhao et al., Cancer Sci 2010
(Carcinoma, Hepatocellular...) :
The
MMP-2 level and invasive potential of HCC cells were
regulated by both annexin II and
HAb18G/CD147
Xie et al., Histochem Cell Biol 2010
:
The current results indicate that
EMMPRIN could thus be
involved in the early stage of tooth germ development and morphogenesis, possibly by regulating the expression of
MMP genes
Wang et al., J Exp Clin Cancer Res 2010
(Stomach Neoplasms) :
Down-regulation of
CD147 by RNAi approach
led to decreased cell proliferation,
MMP-2 and MMP-9 activities and invasive potential of SGC7901 cells as well as increased chemosensitivity to cisplatin
Mishra et al., Reproductive biology and endocrinology : RB&E 2010
:
EMMPRIN from the luminal epithelium may
regulate the expression of stromal
MMP-2 and -14 suggesting its crucial role in adhesion and fusion of embryo to luminal epithelium by directly itself through physiological tissues remodeling and developmental process, and/or stimulating MMPs to compensate endometrial functions
Gou et al., Zhonghua Yi Xue Za Zhi 2010
(Carcinoma, Squamous Cell...) :
CD147 and MMP-2 play a role in invasion and metastasis of laryngeal carcinoma ; increased levels of
MMP-2 and MMP-9 are
induced by
CD147 in laryngeal tumor cells ; MMP-9 may be an independent prognostic factor
Agrawal et al., J Neurosci 2011
(Encephalomyelitis, Autoimmune, Experimental...) :
Together, our results are the first to emphasize a role for EMMPRIN in MS and EAE, whereby
EMMPRIN regulates leukocyte trafficking through increasing
MMP activity
Chen et al., Mol Hum Reprod 2011
:
MMP-2 expression and migration of GC-1 and GC-2 cells were
reduced by interfering with
CD147 expression and function in vitro
Liao et al., Mol Cell Biol 2011
(Carcinoma, Hepatocellular...) :
Overexpression of
basigin-3 inhibited HCC cell proliferation,
MMP induction, and cell invasion in vitro and in vivo
Kawakami et al., BMC cancer 2011
(Adenocarcinoma...) :
Emmprin , a glycoprotein containing two Ig domains, is enriched on tumor cell surfaces and
stimulates matrix metalloproteinase ( MMP ) production by adjacent stromal cells
Huang et al., Biochem J 2013
(Lung Neoplasms) :
Moreover, native glycosylated
CD147 existed exclusively as oligomers in solution and directly
stimulated MMP production more efficiently than non glycosylated prokaryotic CD147
Huang et al., Ann Otol Rhinol Laryngol 2013
(Carcinoma...) :
Nasopharyngeal carcinoma cells may attain enhanced metastastic capability through the expression of
MMP-2 induced by
EMMPRIN
Dang et al., Biochem Pharmacol 2013
:
Prolonged treatment of uterus or aorta of virgin rats with 17ß-estradiol and progesterone increased the amount of EMMPRIN,
MMP-2 and -9, and the sex hormone induced increases in MMPs were
prevented by
EMMPRIN neutralizing antibody
Guo et al., J Biol Chem 1997
:
We show that these transfected cells synthesize EMMPRIN that is extensively post-translationally processed ; this recombinant
EMMPRIN stimulates human fibroblast production of interstitial collagenase, stromelysin-1, and
gelatinase A ( 72-kDa type IV collagenase )
Lim et al., FEBS Lett 1998
(Carcinoma, Non-Small-Cell Lung...) :
EMMPRIN ( extracellular matrix metalloproteinase inducer )
stimulates fibroblast metalloproteinases (
MMP ) 1, 2 and 3 ( Kataoka et al. ( 1993 ) Cancer Res. 53, 3154-3158 )