Ning et al., Am J Respir Cell Mol Biol 2007
(MAP Kinase Signaling System...) :
The identification that induction of MMP-2 and MT1-MMP by CSE from lung fibroblasts is EGR-1 dependent reveals a molecular mechanism for matrix remodeling in cigarette smoke related emphysema
Sanchez-Guerrero et al., PloS one 2012
:
Here we show that Egr-1 expression induced by IL-1beta is dependent on metalloproteinases ( MMP ) and a disintegrin and a metalloproteinase ( ADAM ) ... Pharmacologic MMP/ADAM inhibitors and siRNA knockdown prevent IL-1beta induction of Egr-1