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LEP — PDE3B
Text-mined interactions from Literome
Pyne et al., Diabetologia 2003
:
In contrast, activation of beta-cell
PDE3B could
mediate the inhibitory effect of IGF-1 and
leptin on insulin secretion
Sahu et al., J Neuroendocrinol 2013
:
In the hypothalamus,
leptin stimulates STAT3 activation, and
induces PI3K and
PDE3B activities, among others ... To address this possibility, the effect of wortmannin, a specific PI3K inhibitor, was examined on
leptin induced
PDE3B activity in the hypothalamus of male rats ... However, previous administration of wortmannin completely reversed the stimulatory
effect of
leptin on
PDE3B activity in the hypothalamus
Zhao et al., J Clin Invest 1998
:
In pancreatic beta cells,
leptin causes the activation of
PDE3B , which leads to marked inhibition of glucagon-like peptide-1 stimulated insulin secretion