◀ Back to RELA

FASLG — RELA

Text-mined interactions from Literome

Harwood et al., J Biol Chem 2000 (Colonic Neoplasms) : Regulation of FasL by NF-kappaB and AP-1 in Fas dependent thymineless death of human colon carcinoma cells ... These results demonstrate the crucial roles for NF-kappaB and AP-1 in the regulation of FasL in Fas mediated thymineless death of colon carcinoma cells
Lu et al., Am J Physiol Cell Physiol 2002 : Because TNF-alpha gene expression is under the control of nuclear factor-kappaB (NF-kappaB), we investigated whether FasL can induce NF-kappaB activation and whether such activation plays a role in FasL mediated cell death in macrophages ... Gene transfection studies using NF-kappaB dependent reporter plasmid showed that FasL did activate NF-kappaB promoter activity
Pinkoski et al., J Biol Chem 2002 : TNFalpha induced activation of the Fas-ligand promoter in IEC requires NF-kappaB as this was blocked by an I-kappaBalphaM super-repressor and by mutation of an NF-kappaB site in the Fas-ligand promoter
Martín-Ventura et al., Stroke 2004 (Carotid Artery Diseases) : Nuclear factor-kappaB (NF-kappaB) is involved in the transcriptional regulation of the proapoptotic protein Fas ligand (FasL)
Wurzer et al., J Biol Chem 2004 : NF-kappaB dependent induction of tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and Fas/FasL is crucial for efficient influenza virus propagation ... On a molecular level this is due to NF-kappaB dependent viral induction of the proapoptotic factors tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and FasL , which enhance virus propagation in an autocrine and paracrine fashion
Kreuz et al., J Cell Biol 2004 : However, in the context of Fas signaling both isoforms blocked FasL induced NFkappaB activation ... As NFkappaB signaling is inhibited during apoptosis, FasL induced NFkappaB activation was most prominent in cells that were protected by Bcl2 expression or caspase inhibitors and expressed no or minute amounts of FLIP
Wiener et al., Exp Cell Res 2004 (Carcinoma, Non-Small-Cell Lung...) : In contrast, we observed that overexpression of Max resulted in a marked increase in basal promoter activity and synergistically enhanced phorbolester- and doxorubicin induced NFkappaB mediated Fas ligand promoter activity ... We conclude that high levels of Max and stress induced NFkappaB activation may result in elevated expression of Fas ligand in human lung cancer cells and possibly contribute to Fas ligand associated immune escape mechanisms
Imamura et al., J Biol Chem 2004 (Inflammation) : Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha ... Reporter gene assays involving wild-type and mutated IL-8 promoters and NF-kappaB- and AP-1 reporter constructs indicated that an FasL induced NF-kappaB and AP-1 activity are required for maximal promoter activity ... FasL induced NF-kappaB activation with slower kinetics than did TNF-alpha, yet this response was cell autonomous and not mediated by secondary paracrine factors ... The death domain of Fas, FADD, and caspase-8 were required for NF-kappaB activation by FasL ... A dominant negative mutant of IKKgamma inhibited the FasL induced NF-kappaB activation ... However, TRADD and RIP, which are essential for the TNF-alpha induced NF-kappaB activation, were not involved in the FasL induced NF-kappaB activation ... These results show that FasL induces NF-kappaB activation and IL-8 production by a novel mechanism, distinct from that of TNF-alpha ... In addition, we found that mouse FADD had a dominant negative effect on the FasL induced NF-kappaB activation in HEK293 cells, which may indicate a species difference between human and mouse in the FasL induced NF-kappaB activation
Tsukinoki et al., Clin Exp Nephrol 2004 (Disease Progression...) : Lactacystin mediated inhibition of NFkappaB reduced FasL protein levels
Trauzold et al., FASEB J 2005 (Adenocarcinoma...) : Stimulation of TRAF2 overexpressing cells with CD95 ligand led to induction of NF-kappaB and AP-1, enhanced IL-8- and uPA-secretion, and a further increased invasiveness
Savickiene et al., Int J Biochem Cell Biol 2005 (Leukemia) : p21 ( Waf1/Cip1 ) and FasL gene activation via Sp1 and NFkappaB is required for leukemia cell survival but not for cell death induced by diverse stimuli
Ross et al., J Am Soc Nephrol 2005 (AIDS-Associated Nephropathy...) : Whether the epithelial apoptosis in HIVAN is mediated by NF-kappaB activated Fas ligand expression was investigated here ... These results suggest that NF-kappaB may regulate Fas mediated apoptosis in HIVAN by controlling the expression of Fas ligand in renal epithelium
Peng et al., J Surg Res 2006 (Acute Disease...) : Promoter-reporter assay demonstrated that FasL gene promoter was regulated by NF-kappaB
Wang et al., Asian J Androl 2006 : NF-kappa B is activated by increased FasL/Fas in CORT induced Leydig cell apoptosis
Matsumoto et al., FEBS J 2007 (MAP Kinase Signaling System) : For example, FasL induces nuclear factor kappaB (NF-kappaB) activity and interleukin 8 (IL-8) production by engagement of Fas in human cells
Pan et al., Int J Oncol 2007 (Bile Duct Neoplasms...) : The inverse activities of Fas and FasL promoter in tumor cells are regulated by NF-kappaB , which inhibits Fas expression and increases FasL expression through binding to their respective promoters
Blom et al., BMC cell biology 2010 : We found that S1P protected cells from FasL induced cell death in an NF-kappaB dependent manner
Iyer et al., J Immunol 2011 : Antioxidant c-FLIP inhibits Fas ligand induced NF-kappaB activation in a phosphatidylinositol 3-kinase/Akt dependent manner