Gene interactions and pathways from curated databases and text-mining

◀ Back to IRS1

IL4 — IRS1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Gingras et al., Mol Endocrinol 2000 (Breast Neoplasms) : IL-4 rapidly induced IRS-1 and IRS-2 phosphorylation in ZR-75-1 human breast cancer cell lines
Gingras et al., J Steroid Biochem Mol Biol 2001 : We have also found that IL-4 rapidly induced IRS-1 and IRS-2 phosphorylation in these cell lines
Zamorano et al., Int Immunol 2001 : Moreover, TNF-alpha had no effect on the activation of IRS-1 induced by IL-4
Prokopchuk et al., Br J Cancer 2005 (Pancreatic Neoplasms) : Interleukin-4 enhanced activity of MAPK, Akt-1, and Stat3 in IL-4-responsive, but not in IL-4-unresponsive MIA PaCa-2 cells ; however, IL-4 enhanced tyrosine phosphorylation of insulin receptor substrate-1 and -2 in all cell lines
Kim et al., J Biol Chem 2005 (Inflammation) : In addition, using a phospho-specific antibody against IRS-1 phosphorylated at Ser ( 24 ), we found that interleukin-1 or TNF-alpha treatment of Fao cells stimulated increased phosphorylation of endogenous IRS-1 at Ser ( 24 )
Wang et al., Blood 1995 : These results indicate that IL-13 does not use the IL-2R gamma subunit in its receptor complex and that expression of IL-2R gamma enhances, but is not absolutely required for mediating IL-4 induced tyrosine phosphorylation of IRS-1/4PS
Johnston et al., J Biol Chem 1995 : We report here that IL-2, IL-7, and IL-15, as well as IL-4 , rapidly stimulate the tyrosine phosphorylation of IRS-1 and IRS-2 in human peripheral blood T cells, NK cells, and in lymphoid cell lines ... We further demonstrate that the p85 subunit of phosphoinositol 3-kinase associates with IRS-1 in response to IL-2 and IL-4 in T cells
Keegan et al., Cell 1994 : An IL-4 receptor region containing an insulin receptor motif is important for IL-4 mediated IRS-1 phosphorylation and cell growth
Russell et al., Science 1993 (Severe Combined Immunodeficiency) : IL-2R gamma was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross linking data, the ability of IL-2R gamma to augment IL-4 binding affinity, and the requirement for IL-2R gamma in IL-4 mediated phosphorylation of insulin receptor substrate-1
Wang et al., Science 1993 : Insulin and IL-4 sensitivity was restored to 32D cells by expression of IRS-1 , the principal substrate of the insulin receptor
Burfoot et al., J Biol Chem 1997 : Janus kinase dependent activation of insulin receptor substrate 1 in response to interleukin-4 , oncostatin M, and the interferons ... In addition to a role in response to insulin and insulin-like growth factors, insulin receptor substrate 1 (IRS-1) is phosphorylated in response to IL-4 , the interferons ( IFNs ) and oncostatin M (OSM) ... In contrast, phosphorylation of IRS-1 mediated by the Type I IFNs, IL-4 , and OSM is JAK dependent