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ANXA6 — RAC1
Text-mined interactions from Literome
Lambert et al., J Biol Chem 2002
:
First, we found that Rac1 transforming activity could be dissociated from
Rac1 activation of
p70 ( S6K ) ... These data suggest that
p70 ( S6K ) is not
necessary to promote full
Rac1 transforming activity ... We found that the MLK3 serine/threonine kinase activated JNK and p70 ( S6K ), whereas
activation of
p70 ( S6K ) by
Rac ( 61L ) was significantly inhibited by dominant negative MLK3 ... Taken together, these results provide evidence that
Rac1 coordinately
activates p70 ( S6K ) and JNK via MLK3 activation
Aitsebaomo et al., J Biol Chem 2004
(Neovascularization, Pathologic) :
Functionally
p68RacGAP specifically
activates the GTPase activity of
Rac1 in vivo but not Cdc42 or RhoA