Gene interactions and pathways from curated databases and text-mining

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ANXA6 — RAC1

Text-mined interactions from Literome

Lambert et al., J Biol Chem 2002 : First, we found that Rac1 transforming activity could be dissociated from Rac1 activation of p70 ( S6K ) ... These data suggest that p70 ( S6K ) is not necessary to promote full Rac1 transforming activity ... We found that the MLK3 serine/threonine kinase activated JNK and p70 ( S6K ), whereas activation of p70 ( S6K ) by Rac ( 61L ) was significantly inhibited by dominant negative MLK3 ... Taken together, these results provide evidence that Rac1 coordinately activates p70 ( S6K ) and JNK via MLK3 activation
Aitsebaomo et al., J Biol Chem 2004 (Neovascularization, Pathologic) : Functionally p68RacGAP specifically activates the GTPase activity of Rac1 in vivo but not Cdc42 or RhoA