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RAC1 — RHOG

Pathways - manually collected, often from reviews:

• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAC1/GDP complex (RAC1) → RhoG/GTP/ELMO1/DOCK1 complex (RHOG-ELMO1-DOCK1) (modification, collaborate)
  Katoh et al., Nature 2003
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Katoh et al., Nature 2003 : RhoG activates Rac1 by direct interaction with the Dock180 binding protein Elmo ... The small GTPase RhoG mediates several cellular morphological processes, such as neurite outgrowth in neuronal cells, through a signalling cascade that activates Rac1 ( refs 7-12 ) ; however, the downstream target of RhoG and the mechanism by which RhoG regulates Rac1 activity remain unclear
Aspenström et al., Biochem J 2004 : Cdc42, TCL ( TC10-like ), Rac1-Rac3 and RhoG induced the formation of lamellipodia, whereas Cdc42, Rac1 and Rac2 also induced the formation of thick bundles of actin filaments
Katoh et al., J Cell Sci 2006 : Activation of Rac1 by RhoG regulates cell migration ... The small GTPase RhoG activates Rac through its effector ELMO and the ELMO binding protein Dock180, which functions as a Rac-specific guanine nucleotide exchange factor ... Taken together, these results suggest that RhoG contributes to the regulation of Rac activity in migrating cells
Yamaki et al., Exp Cell Res 2007 : Previous studies have shown that RhoG activates Rac1 and induces several cellular functions including promotion of cell migration through its effector ELMO and the ELMO binding protein Dock180 that function as a Rac-specific guanine nucleotide exchange factor