Binet et al., Cancer Res 2009
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WNT16B expression is required for the full transcriptional activation of p21 ( WAF1 )
Lüdtke et al., PLoS Genet 2013
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Prior to the observed cellular changes, canonical Wnt signaling was downregulated, and Cdkn1a ( p21 ) and Cdkn1b ( p27 ) ( two members of the Cip/Kip family of cell cycle inhibitors ) were strongly induced in the Tbx2-deficient lung mesenchyme