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PKN2 — RAC1
Text-mined interactions from Literome
Bourguignon et al., J Biol Chem 2004
(Calcium Signaling) :
Hyaluronan-CD44 interaction with
Rac1 dependent
protein kinase N-gamma promotes phospholipase Cgamma1 activation, Ca ( 2+ ) signaling, and cortactin-cytoskeleton function leading to keratinocyte adhesion and differentiation ... The binding of HA to keratinocytes promotes PKNgamma kinase recruitment into a complex with CD44 and subsequently stimulates
Rac1 mediated
PKNgamma kinase activity
Bourguignon et al., J Neurochem 2007
:
We determined that HA binding to astrocytes stimulated
Rac1 dependent
PKN gamma kinase activity which, in turn, up-regulated the phosphorylation of the cytoskeletal protein, cortactin, and attenuated the ability of cortactin to cross-link F-actin