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CSF2 — SPP1

Text-mined interactions from Literome

Lin et al., Mol Cell Biol 2000 : Antibody blocking experiments revealed that OPN produced as a result of IL-3 or GM-CSF signaling was secreted into the medium and, through binding to its cell surface receptor, CD44, contributed to the survival promoting activities of these two cytokines
Lin et al., J Biol Chem 2001 : We have recently demonstrated that the gene encoding the osteopontin (OPN) protein is activated both by interleukin-3 and granulocyte-macrophage colony stimulating factor signaling pathways and that, through binding to the cell surface receptor CD44, OPN contributes to the survival activities of interleukin (IL)-3 and GM-CSF ( Lin, Y.-H., Huang, C.-J., Chao, J.-R., Chen, S.-T., Lee, S.-F., Yen, J. J.-Y., and Yang-Yen, H.-F
Koguchi et al., Infect Immun 2002 (AIDS-Related Opportunistic Infections) : We also examined the regulatory role of granulocyte-macrophage colony stimulating factor ( GM-CSF ) in OPN secretion from P. marneffei stimulated PBMCs. Neutralizing anti-GM-CSF MAb significantly reduced OPN secretion, and treatment with this cytokine induced OPN production from both infected and noninfected PBMCs ... Our results demonstrated that OPN secreted from monocytes is involved in the production of IL-12 from PBMCs after stimulation with P. marneffei and that OPN production is regulated by GM-CSF