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Hsu et al., Circulation 2010
(Myocardial Reperfusion Injury) :
Sirt1 positively regulates expression of prosurvival molecules, including manganese superoxide dismutase, thioredoxin-1, and Bcl-xL , whereas it negatively regulates the proapoptotic molecules Bax and cleaved caspase-3
Seo et al., Neurobiol Aging 2012
:
SIRT1 activation also inhibited PrP ( 106-126 ) -mediated p38 mitogen activating protein kinase ( MAPK ) activation and caspase-3 cleavage, and increased the expression of anti-apoptotic Bcl-xL protein
Tiberi et al., Nat Neurosci 2012
:
Our findings suggest a role for BCL6 in neurogenesis and uncover Notch-BCL6-Sirt1 interactions that may affect other aspects of physiology and disease